Articles producció científica> Ciències Mèdiques Bàsiques

Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group

  • Datos identificativos

    Identificador: imarina:9286636
    Autores:
    Eraso, ArantxaSanz, JavierMolla, MeritxellReyes, VickyPedro, AgustiArenas, MeritxellMartinez, EvelynBallester, RosaJose Cambra, MariaGarcia, VirginiaLluis Prades, JoanBorras, Josep M.Algara, Manuel
    Resumen:
    Introduction Daily, moderate hypofractionation has become standard treatment for breast cancer following breast-conserving surgery, although substantial variation exists in its use. This paper describes the generation of consensus-based recommendations for the utilisation of this therapy at the healthcare system level and compares these to American Society for Radiation Oncology (ASTRO) guidelines. Materials and methods Consensus-based guidelines were developed in three steps, including a systematic literature review and involvement of radiation oncologists specialising in breast cancer in Catalonia: (a) creation of a working group and evidence review; (b) consideration of the levels of evidence and agreement on the formulation of survey questions; and (c) performance of survey and development of consensus-based recommendations. Results were compared to the ASTRO recommendations. Results Consensus was above 80% for 10 of the 14 survey items. Experts supported hypofractionated radiotherapy for all breast cancer patients aged 40 years or more; with invasive carcinoma and breast-conserving surgery; without radiation of lymph nodes; and regardless of the tumour size, histological grade, molecular subtype, breast size, laterality, other treatment characteristics, or need for a boost. Over half favoured its use in all situations, even where available scientific evidence is insufficient. The resulting recommendations and the quality of the evidence are comparable to those from ASTRO, despite some differences in the degree of consensus. Conclusion Specialists agree that hypofractionation is the standard treatment for breast cancer following breast-conserving surgery, but some specific areas require a higher level of evidence before unequivocally extending indications.
  • Otros:

    Autor según el artículo: Eraso, Arantxa; Sanz, Javier; Molla, Meritxell; Reyes, Vicky; Pedro, Agusti; Arenas, Meritxell; Martinez, Evelyn; Ballester, Rosa; Jose Cambra, Maria; Garcia, Virginia; Lluis Prades, Joan; Borras, Josep M.; Algara, Manuel;
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Arenas Prat, Meritxell
    Palabras clave: Women Therapy Randomized-trial Radiotherapy Irradiation Hypofractionation Breast cancer
    Resumen: Introduction Daily, moderate hypofractionation has become standard treatment for breast cancer following breast-conserving surgery, although substantial variation exists in its use. This paper describes the generation of consensus-based recommendations for the utilisation of this therapy at the healthcare system level and compares these to American Society for Radiation Oncology (ASTRO) guidelines. Materials and methods Consensus-based guidelines were developed in three steps, including a systematic literature review and involvement of radiation oncologists specialising in breast cancer in Catalonia: (a) creation of a working group and evidence review; (b) consideration of the levels of evidence and agreement on the formulation of survey questions; and (c) performance of survey and development of consensus-based recommendations. Results were compared to the ASTRO recommendations. Results Consensus was above 80% for 10 of the 14 survey items. Experts supported hypofractionated radiotherapy for all breast cancer patients aged 40 years or more; with invasive carcinoma and breast-conserving surgery; without radiation of lymph nodes; and regardless of the tumour size, histological grade, molecular subtype, breast size, laterality, other treatment characteristics, or need for a boost. Over half favoured its use in all situations, even where available scientific evidence is insufficient. The resulting recommendations and the quality of the evidence are comparable to those from ASTRO, despite some differences in the degree of consensus. Conclusion Specialists agree that hypofractionation is the standard treatment for breast cancer following breast-conserving surgery, but some specific areas require a higher level of evidence before unequivocally extending indications.
    Áreas temáticas: Saúde coletiva Oncology Odontología Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Farmacia Engenharias ii Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: meritxell.arenas@urv.cat
    Identificador del autor: 0000-0003-0815-2570
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s12094-022-02798-8
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Clinical & Translational Oncology. 24 (8): 1580-1587
    Referencia de l'ítem segons les normes APA: Eraso, Arantxa; Sanz, Javier; Molla, Meritxell; Reyes, Vicky; Pedro, Agusti; Arenas, Meritxell; Martinez, Evelyn; Ballester, Rosa; Jose Cambra, Maria; (2022). Evidence-based guidelines for hypofractionated radiation in breast cancer: conclusions of the Catalan expert working group. Clinical & Translational Oncology, 24(8), 1580-1587. DOI: 10.1007/s12094-022-02798-8
    DOI del artículo: 10.1007/s12094-022-02798-8
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cancer Research,Medicine (Miscellaneous),Oncology
    Women
    Therapy
    Randomized-trial
    Radiotherapy
    Irradiation
    Hypofractionation
    Breast cancer
    Saúde coletiva
    Oncology
    Odontología
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Farmacia
    Engenharias ii
    Ciências biológicas ii
    Ciências biológicas i
    Cancer research
    Biotecnología
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