Autor según el artículo: Davogustto GE; Salazar RL; Vasquez HG; Karlstaedt A; Dillon WP; Guthrie PH; Martin JR; Vitrac H; De La Guardia G; Vela D; Ribas-Latre A; Baumgartner C; Eckel-Mahan K; Taegtmeyer H
Departamento: Medicina i Cirurgia
Autor/es de la URV: Ribas Latre, Aleix
Palabras clave: Mtorc1 Metabolism Hypertrophy Glycolysis Exercise
Resumen: Rationale: The nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) and its primary inhibitor, tuberin (TSC2), are cues for the development of cardiac hypertrophy. The phenotype of mTORC1 induced hypertrophy is unknown. Objective: To examine the impact of sustained mTORC1 activation on metabolism, function, and structure of the adult heart. Methods and results: We developed a mouse model of inducible, cardiac-specific sustained mTORC1 activation (mTORC1iSA) through deletion of Tsc2. Prior to hypertrophy, rates of glucose uptake and oxidation, as well as protein and enzymatic activity of glucose 6-phosphate isomerase (GPI) were decreased, while intracellular levels of glucose 6-phosphate (G6P) were increased. Subsequently, hypertrophy developed. Transcript levels of the fetal gene program and pathways of exercise-induced hypertrophy increased, while hypertrophy did not progress to heart failure. We therefore examined the hearts of wild-type mice subjected to voluntary physical activity and observed early changes in GPI, followed by hypertrophy. Rapamycin prevented these changes in both models. Conclusion: Activation of mTORC1 in the adult heart triggers the development of a non-specific form of hypertrophy which is preceded by changes in cardiac glucose metabolism.
Áreas temáticas: Química Psicología Nutrição Molecular biology Medicina veterinaria Medicina ii Medicina i General medicine Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cell biology Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: aleix.ribas@urv.cat
Fecha de alta del registro: 2023-02-19
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.jmcc-online.com/article/S0022-2828(21)00110-3/fulltext
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of Molecular And Cellular Cardiology. 158 115-127
Referencia de l'ítem segons les normes APA: Davogustto GE; Salazar RL; Vasquez HG; Karlstaedt A; Dillon WP; Guthrie PH; Martin JR; Vitrac H; De La Guardia G; Vela D; Ribas-Latre A; Baumgartner C (2021). Metabolic remodeling precedes mTORC1-mediated cardiac hypertrophy. Journal Of Molecular And Cellular Cardiology, 158(), 115-127. DOI: 10.1016/j.yjmcc.2021.05.016
DOI del artículo: 10.1016/j.yjmcc.2021.05.016
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2021
Tipo de publicación: Journal Publications
Repositori URV