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Combining Dietary Intervention with Metformin Treatment Enhances Non-Alcoholic Steatohepatitis Remission in Mice Fed a High-Fat High-Sucrose Diet

  • Datos identificativos

    Identificador: imarina:9287631
    Autores:
    Baiges-Gaya GRodríguez-Tomàs ECastañé HJiménez-Franco AAmigó NCamps JJoven J
    Resumen:
    Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are serious health concerns for which lifestyle interventions are the only effective first-line treatment. Dietary interventions are effective in body weight reduction, but not in improving insulin sensitivity and hepatic lipid mobilization. Conversely, metformin increases insulin sensitivity and promotes the inhibition of de novo hepatic lipogenesis. In this study, we evaluated the metformin effectiveness in NASH prevention and treatment, when combined with dietary intervention in male mice fed a high-fat high-sucrose diet (HFHSD). Eighty 5-week-old C57BL/6J male mice were fed a chow or HFHSD diet and sacrificed at 20 or 40 weeks. The HFHSD-fed mice developed NASH after 20 weeks. Lipoprotein and lipidomic analyses showed that the changes associated with diet were not prevented by metformin administration. HFHSD-fed mice subject to dietary intervention combined with metformin showed a 19.6% body weight reduction compared to 9.8% in those mice subjected to dietary intervention alone. Lower hepatic steatosis scores were induced. We conclude that metformin should not be considered a preventive option for NAFLD, but it is effective in the treatment of this disorder when combined with dietary intervention.
  • Otros:

    Autor según el artículo: Baiges-Gaya G; Rodríguez-Tomàs E; Castañé H; Jiménez-Franco A; Amigó N; Camps J; Joven J
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Camps Andreu, Jorge / Joven Maried, Jorge
    Palabras clave: Obesity Nafld Mice Liver Lipidomic Hepatic steatosis Adipose tissue therapy phosphatidylcholine obese nafld mice metabolism liver lipidomic insulin-binding induction deficiency autophagy adipose tissue
    Resumen: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are serious health concerns for which lifestyle interventions are the only effective first-line treatment. Dietary interventions are effective in body weight reduction, but not in improving insulin sensitivity and hepatic lipid mobilization. Conversely, metformin increases insulin sensitivity and promotes the inhibition of de novo hepatic lipogenesis. In this study, we evaluated the metformin effectiveness in NASH prevention and treatment, when combined with dietary intervention in male mice fed a high-fat high-sucrose diet (HFHSD). Eighty 5-week-old C57BL/6J male mice were fed a chow or HFHSD diet and sacrificed at 20 or 40 weeks. The HFHSD-fed mice developed NASH after 20 weeks. Lipoprotein and lipidomic analyses showed that the changes associated with diet were not prevented by metformin administration. HFHSD-fed mice subject to dietary intervention combined with metformin showed a 19.6% body weight reduction compared to 9.8% in those mice subjected to dietary intervention alone. Lower hepatic steatosis scores were induced. We conclude that metformin should not be considered a preventive option for NAFLD, but it is effective in the treatment of this disorder when combined with dietary intervention.
    Áreas temáticas: Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat
    Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2218-273X/12/12/1787
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Biomolecules. 12 (12):
    Referencia de l'ítem segons les normes APA: Baiges-Gaya G; Rodríguez-Tomàs E; Castañé H; Jiménez-Franco A; Amigó N; Camps J; Joven J (2022). Combining Dietary Intervention with Metformin Treatment Enhances Non-Alcoholic Steatohepatitis Remission in Mice Fed a High-Fat High-Sucrose Diet. Biomolecules, 12(12), -. DOI: 10.3390/biom12121787
    DOI del artículo: 10.3390/biom12121787
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Biochemistry & Molecular Biology,Molecular Biology
    Obesity
    Nafld
    Mice
    Liver
    Lipidomic
    Hepatic steatosis
    Adipose tissue
    therapy
    phosphatidylcholine
    obese
    nafld
    mice
    metabolism
    liver
    lipidomic
    insulin-binding
    induction
    deficiency
    autophagy
    adipose tissue
    Química
    Molecular biology
    Materiais
    General medicine
    Farmacia
    Ensino
    Biochemistry & molecular biology
    Biochemistry
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