Autor según el artículo: Baiges-Gaya G; Rodríguez-Tomàs E; Castañé H; Jiménez-Franco A; Amigó N; Camps J; Joven J
Departamento: Medicina i Cirurgia
Autor/es de la URV: Camps Andreu, Jorge / Joven Maried, Jorge
Palabras clave: Obesity Nafld Mice Liver Lipidomic Hepatic steatosis Adipose tissue therapy phosphatidylcholine obese nafld mice metabolism liver lipidomic insulin-binding induction deficiency autophagy adipose tissue
Resumen: Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are serious health concerns for which lifestyle interventions are the only effective first-line treatment. Dietary interventions are effective in body weight reduction, but not in improving insulin sensitivity and hepatic lipid mobilization. Conversely, metformin increases insulin sensitivity and promotes the inhibition of de novo hepatic lipogenesis. In this study, we evaluated the metformin effectiveness in NASH prevention and treatment, when combined with dietary intervention in male mice fed a high-fat high-sucrose diet (HFHSD). Eighty 5-week-old C57BL/6J male mice were fed a chow or HFHSD diet and sacrificed at 20 or 40 weeks. The HFHSD-fed mice developed NASH after 20 weeks. Lipoprotein and lipidomic analyses showed that the changes associated with diet were not prevented by metformin administration. HFHSD-fed mice subject to dietary intervention combined with metformin showed a 19.6% body weight reduction compared to 9.8% in those mice subjected to dietary intervention alone. Lower hepatic steatosis scores were induced. We conclude that metformin should not be considered a preventive option for NAFLD, but it is effective in the treatment of this disorder when combined with dietary intervention.
Áreas temáticas: Química Molecular biology Materiais General medicine Farmacia Ensino Biochemistry & molecular biology Biochemistry
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jorge.camps@urv.cat jorge.joven@urv.cat
Identificador del autor: 0000-0002-3165-3640 0000-0003-2749-4541
Fecha de alta del registro: 2024-09-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2218-273X/12/12/1787
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Biomolecules. 12 (12):
Referencia de l'ítem segons les normes APA: Baiges-Gaya G; Rodríguez-Tomàs E; Castañé H; Jiménez-Franco A; Amigó N; Camps J; Joven J (2022). Combining Dietary Intervention with Metformin Treatment Enhances Non-Alcoholic Steatohepatitis Remission in Mice Fed a High-Fat High-Sucrose Diet. Biomolecules, 12(12), -. DOI: 10.3390/biom12121787
DOI del artículo: 10.3390/biom12121787
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2022
Tipo de publicación: Journal Publications