Articles producció científica> Ciències Mèdiques Bàsiques

Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet

  • Datos identificativos

    Identificador: imarina:9287665
    Autores:
    Miralles-Pérez BNogués MRSánchez-Martos VFortuño-Mar ÀRamos-Romero STorres JLPonomarenko JAmézqueta SZhang XRomeu M
    Resumen:
    The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar–Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After 10 weeks, the HF + Inulin diet promoted high dominance of a few bacterial genera including Blautia and Olsenella in feces while reducing richness, diversity, and rarity compared to the HF diet. These changes in fecal microbiota were accompanied by an increased amount of propionic acid in feces. The HF + Inulin diet decreased cardiometabolic risk factors, decreased the amount of the eicosanoids 11(12)-EET and 15-HETrE in the liver, and decreased oxidative stress in blood compared to the HF diet. In conclusion, increasing consumption of inulin may be a useful nutritional strategy to protect against the onset of obesity and its associated metabolic abnormalities by means of modulation of gut microbiota.
  • Otros:

    Autor según el artículo: Miralles-Pérez B; Nogués MR; Sánchez-Martos V; Fortuño-Mar À; Ramos-Romero S; Torres JL; Ponomarenko J; Amézqueta S; Zhang X; Romeu M
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Miralles Pérez, Bernat / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / Sánchez Martos, Vanessa
    Palabras clave: Obesity Lipid peroxidation Insulin-resistance Insulin resistance Gut microbiota Glucose intolerance Fatty liver Endogenous antioxidants Dyslipidemia plasma lipid peroxidation insulin resistance induced obesity gut microbiota glucose intolerance glucose gene-expression fiber fatty liver endogenous antioxidants dyslipidemia catalase assay acid
    Resumen: The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar–Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After 10 weeks, the HF + Inulin diet promoted high dominance of a few bacterial genera including Blautia and Olsenella in feces while reducing richness, diversity, and rarity compared to the HF diet. These changes in fecal microbiota were accompanied by an increased amount of propionic acid in feces. The HF + Inulin diet decreased cardiometabolic risk factors, decreased the amount of the eicosanoids 11(12)-EET and 15-HETrE in the liver, and decreased oxidative stress in blood compared to the HF diet. In conclusion, increasing consumption of inulin may be a useful nutritional strategy to protect against the onset of obesity and its associated metabolic abnormalities by means of modulation of gut microbiota.
    Áreas temáticas: Plant science Microbiology Health professions (miscellaneous) Health (social science) Food science & technology Food science
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: bernat.miralles@urv.cat vanessa.sanchez@urv.cat vanessa.sanchez@urv.cat marta.romeu@urv.cat
    Identificador del autor: 0000-0003-1294-7069 0000-0002-2131-1858
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2304-8158/11/24/4072
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Foods. 11 (24):
    Referencia de l'ítem segons les normes APA: Miralles-Pérez B; Nogués MR; Sánchez-Martos V; Fortuño-Mar À; Ramos-Romero S; Torres JL; Ponomarenko J; Amézqueta S; Zhang X; Romeu M (2022). Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet. Foods, 11(24), -. DOI: 10.3390/foods11244072
    DOI del artículo: 10.3390/foods11244072
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Food Science,Food Science & Technology,Health (Social Science),Health Professions (Miscellaneous),Microbiology,Plant Science
    Obesity
    Lipid peroxidation
    Insulin-resistance
    Insulin resistance
    Gut microbiota
    Glucose intolerance
    Fatty liver
    Endogenous antioxidants
    Dyslipidemia
    plasma
    lipid peroxidation
    insulin resistance
    induced obesity
    gut microbiota
    glucose intolerance
    glucose
    gene-expression
    fiber
    fatty liver
    endogenous antioxidants
    dyslipidemia
    catalase
    assay
    acid
    Plant science
    Microbiology
    Health professions (miscellaneous)
    Health (social science)
    Food science & technology
    Food science
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