Autor según el artículo: Lejeune, M; Reverté, L; Sauras, E; Gallardo, N; Bosch, R; Roso, A; Petit, A; Peg, V; Riu, F; García-Fontgivell, J; Ibáñez, J; Relea, F; Vieites, B; Bor, C; de la Cruz-Merino, L; Arenas, M; Rodriguez, V; Galera, J; Korzynska, A; Belhomme, P; Plancoulaine, B; Alvaro, T; López, C
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Arenas Prat, Meritxell / Bosch Príncep, Ramon / Galera Ortega, Juana / Garcia Fontgivell, Joan Francesc / Lejeune, Marylène Marie / Lopez Pablo, Carlos / Sauras Colón, Esther
Palabras clave: Tumor microenvironment Triple-negative breast cancer Survival Relapse Neoadjuvant therapy Infiltrating lymphocytes Immune markers Genetic markers tumor microenvironment survival standard signature risk relapse neoadjuvant therapy immune markers identification genetic markers
Resumen: With a high risk of relapse and death, and a poor or absent response to therapeutics, the triple-negative breast cancer (TNBC) subtype is particularly challenging, especially in patients who cannot achieve a pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). Although the tumor microenvironment (TME) is known to influence disease progression and the effectiveness of therapeutics, its predictive and prognostic potential remains uncertain. This work aimed to define the residual TME profile after NAC of a retrospective cohort with 96 TNBC patients by immunohistochemical staining (cell markers) and chromogenic in situ hybridization (genetic markers). Kaplan–Meier curves were used to estimate the influence of the selected TME markers on five-year overall survival (OS) and relapse-free survival (RFS) probabilities. The risks of each variable being associated with relapse and death were determined through univariate and multivariate Cox analyses. We describe a unique tumor-infiltrating immune profile with high levels of lymphocytes (CD4, FOXP3) and dendritic cells (CD21, CD1a and CD83) that are valuable prognostic factors in post-NAC TNBC patients. Our study also demonstrates the value of considering not only cellular but also genetic TME markers such as MUC-1 and CXCL13 in routine clinical diagnosis to refine prognosis modelling.
Áreas temáticas: Oncology Medicina iii Cancer research
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: joanfrancesc.garcia@urv.cat ramon.bosch@urv.cat juana.galera@urv.cat carlos.lopez@urv.cat marylenemarie.lejeune@urv.cat meritxell.arenas@urv.cat ramon.bosch@urv.cat esther.sauras@estudiants.urv.cat
Identificador del autor: 0000-0003-1248-3065 0000-0001-8441-9404 0000-0003-0815-2570
Fecha de alta del registro: 2024-06-22
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6694/15/3/597
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Cancers. 15 (3):
Referencia de l'ítem segons les normes APA: Lejeune, M; Reverté, L; Sauras, E; Gallardo, N; Bosch, R; Roso, A; Petit, A; Peg, V; Riu, F; García-Fontgivell, J; Ibáñez, J; Relea, F; Vieites, B; Bo (2023). Prognostic Implications of the Residual Tumor Microenvironment after Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer Patients without Pathological Complete Response. Cancers, 15(3), -. DOI: 10.3390/cancers15030597
DOI del artículo: 10.3390/cancers15030597
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV