Gut Microbiota Influences the Photoperiod Effects on Proanthocyanidins Bioavailability in Diet-Induced Obese Rats

Identificador:  imarina:9292143

Handle: https://hdl.handle.net/20.500.11797/imarina9292143

Autores:  Arreaza-Gil, V; Escobar-Martínez, I; Mulero, M; Muguerza, B; Suárez, M; Arola-Arnal, A; Torres-Fuentes, C

Resumen:
Polyphenols health effects on obesity are mainly attributed to their metabolites generated after their gastrointestinal digestion, in which gut microbiota plays an important role. Moreover, gut microbiota composition and polyphenols bioavailability are influenced by differences in day light length (photoperiod). Thus, this study evaluated if a grape seed proanthocyanidins extract (GSPE) bioavailability is influenced by different photoperiod exposure via gut microbiota modulation in an obesogenic context.Cafeteria diet-induced obese Fischer 344 rats were housed under different photoperiod conditions (6, 12 or 18 h of light per day) during 9 weeks and administered with GSPE (25 mg/kg) or GSPE and an antibiotic cocktail (ABX) for the last 4 weeks. Serum GSPE-derived metabolites were quantified by HPLC-MS/MS.A higher bioavailability was observed under L6 compared to L18. Individual metabolites, especially those from the gut microbiota, were affected by photoperiods. ABX treatment altered these photoperiod-mediated changes. Therefore, these results suggest that gut microbiota plays a key role in the photoperiod effects on GSPE bioavailability in obese rats. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.