Autor según el artículo: Castillejo, G; Ochoa-Sangrador, C; Perez-Solis, D; Cilleruelo, ML; Donat, E; Garcia-Burriel, JI; Sanchez-Valverde, F; Garcia-Calatayud, S; Eizaguirre, FJ; Martinez-Ojinaga, E; Barros, P; Leis, R; Salazar, JC; Barrio, J; Pena-Quintana, L; Luque, V; Polanco, I; Ribes, C; Roman, E
Departamento: Medicina i Cirurgia
Autor/es de la URV: Castillejo De Villasante, Gemma / Luque Moreno, Verònica
Palabras clave: Screening Quality-of-life Prevalence Population Pediatric gastroenterology Long-term health Health-care services General practice Follow-up Diagnosis Consequences Coeliac disease Children Adolescents
Resumen: The worldwide prevalence of asymptomatic coeliac disease (CD) is increasing, which is in part due to the routine screening of children with risk factors. Both symptomatic and asymptomatic patients with CD are at risk of long-term complications. The objective of this study was to compare the clinical characteristics of asymptomatic and symptomatic children at the time of CD diagnosis. A case-control study was conducted using data from a cohort of 4838 CD patients recruited from 73 centers across Spain between 2011 and 2017. A total of 468 asymptomatic patients (cases) were selected and matched by age and sex with 468 symptomatic patients (controls). Clinical data, including any reported symptoms, as well as serologic, genetic, and histopathologic data were collected. No significant differences were found between the two groups in most clinical variables, nor in the degree of intestinal lesion. However, the asymptomatic patients were taller (height z-score -0.12 (1.06) vs. -0.45 (1.19), p < 0.001) and were less likely to have anti transglutaminase IgA antibodies >= 10 times the upper normal limit (66.2% vs. 758.4%, p = 0.002). Among the 37.1% of asymptomatic patients who were not screened for CD due to the absence of risk factors, only 34% were truly asymptomatic, while the remaining 66% reported non-specific CD-related symptoms. Therefore, expanding CD screening to any child who undergoes a blood test could reduce the burden of care for some children, as many of those considered asymptomatic reported non-specific CD-related symptoms.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: veronica.luque@urv.cat gemma.castillejo@urv.cat
Identificador del autor: 0000-0003-2615-8175
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/15/5/1267
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 15 (5):
Referencia de l'ítem segons les normes APA: Castillejo, G; Ochoa-Sangrador, C; Perez-Solis, D; Cilleruelo, ML; Donat, E; Garcia-Burriel, JI; Sanchez-Valverde, F; Garcia-Calatayud, S; Eizaguirre, (2023). Coeliac Disease Case-Control Study: Has the Time Come to Explore beyond Patients at Risk?. Nutrients, 15(5), -. DOI: 10.3390/nu15051267
DOI del artículo: 10.3390/nu15051267
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications