Articles producció científica> Química Analítica i Química Orgànica

Assembling Complex Macromolecules and Self-Organizations of Biological Relevance with Cu(I)-Catalyzed Azide-Alkyne, Thio-Bromo, and TERMINI Double "Click" Reactions

  • Datos identificativos

    Identificador: imarina:9294212
    Autores:
    Moreno, ALligadas, GAdamson, JMaurya, DSPercec, V
    Resumen:
    In 2022, the Nobel Prize in Chemistry was awarded to Bertozzi, Meldal, and Sharpless "for the development of click chemistry and biorthogonal chemistry". Since 2001, when the concept of click chemistry was advanced by Sharpless laboratory, synthetic chemists started to envision click reactions as the preferred choice of synthetic methodology employed to create new functions. This brief perspective will summarize research performed in our laboratories with the classic Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction elaborated by Meldal and Sharpless, with the thio-bromo click (TBC) and with the less-used, irreversible TERminator Multifunctional INItiator (TERMINI) dual click (TBC) reactions, the last two elaborated in our laboratory. These click reactions will be used to assemble, by accelerated modular-orthogonal methodologies, complex macromolecules and self-organizations of biological relevance. Self-assembling amphiphilic Janus dendrimers and Janus glycodendrimers together with their biological membrane mimics known as dendrimersomes and glycodendrimersomes as well as simple methodologies to assemble macromolecules with perfect and complex architecture such as dendrimers from commercial monomers and building blocks will be discussed. This perspective is dedicated to the 75th anniversary of Professor Bogdan C. Simionescu, the son of my (VP) Ph.D. mentor, Professor Cristofor I. Simionescu, who as his father, took both science and science administration in his hands, and dedicated his life to handling them in a tandem way, to their best.
  • Otros:

    Autor según el artículo: Moreno, A; Lligadas, G; Adamson, J; Maurya, DS; Percec, V
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: Lligadas Puig, Gerard / Moreno Guerra, Adrian
    Palabras clave: Ultrafast set-lrp Thio-bromo click Termini dual click Single-electron-transfer Raft polymerization Programmable glycan presentation Multiblock copolymers Modular-orthogonal methodology Methyl acrylate Living radical polymerization Glycodendrimersomes Dendritic macromolecules Dendrimersomes Dendrimers Defined janus glycodendrimers Cu(i)-catalyzed azide-alkyne click Click reactions Biological membranes 1,3-dipolar cycloadditions
    Resumen: In 2022, the Nobel Prize in Chemistry was awarded to Bertozzi, Meldal, and Sharpless "for the development of click chemistry and biorthogonal chemistry". Since 2001, when the concept of click chemistry was advanced by Sharpless laboratory, synthetic chemists started to envision click reactions as the preferred choice of synthetic methodology employed to create new functions. This brief perspective will summarize research performed in our laboratories with the classic Cu(I)-catalyzed azide-alkyne click (CuAAC) reaction elaborated by Meldal and Sharpless, with the thio-bromo click (TBC) and with the less-used, irreversible TERminator Multifunctional INItiator (TERMINI) dual click (TBC) reactions, the last two elaborated in our laboratory. These click reactions will be used to assemble, by accelerated modular-orthogonal methodologies, complex macromolecules and self-organizations of biological relevance. Self-assembling amphiphilic Janus dendrimers and Janus glycodendrimers together with their biological membrane mimics known as dendrimersomes and glycodendrimersomes as well as simple methodologies to assemble macromolecules with perfect and complex architecture such as dendrimers from commercial monomers and building blocks will be discussed. This perspective is dedicated to the 75th anniversary of Professor Bogdan C. Simionescu, the son of my (VP) Ph.D. mentor, Professor Cristofor I. Simionescu, who as his father, took both science and science administration in his hands, and dedicated his life to handling them in a tandem way, to their best.
    Áreas temáticas: Polymers and plastics Polymer science Odontología General chemistry Farmacia Engenharias ii Ciências biológicas ii Chemistry (miscellaneous) Chemistry (all) Biotecnología Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: adrian.moreno@urv.cat gerard.lligadas@urv.cat
    Identificador del autor: 0000-0002-8519-1840
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2073-4360/15/5/1075
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Polymers. 15 (5):
    Referencia de l'ítem segons les normes APA: Moreno, A; Lligadas, G; Adamson, J; Maurya, DS; Percec, V (2023). Assembling Complex Macromolecules and Self-Organizations of Biological Relevance with Cu(I)-Catalyzed Azide-Alkyne, Thio-Bromo, and TERMINI Double "Click" Reactions. Polymers, 15(5), -. DOI: 10.3390/polym15051075
    DOI del artículo: 10.3390/polym15051075
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemistry (Miscellaneous),Polymer Science,Polymers and Plastics
    Ultrafast set-lrp
    Thio-bromo click
    Termini dual click
    Single-electron-transfer
    Raft polymerization
    Programmable glycan presentation
    Multiblock copolymers
    Modular-orthogonal methodology
    Methyl acrylate
    Living radical polymerization
    Glycodendrimersomes
    Dendritic macromolecules
    Dendrimersomes
    Dendrimers
    Defined janus glycodendrimers
    Cu(i)-catalyzed azide-alkyne click
    Click reactions
    Biological membranes
    1,3-dipolar cycloadditions
    Polymers and plastics
    Polymer science
    Odontología
    General chemistry
    Farmacia
    Engenharias ii
    Ciências biológicas ii
    Chemistry (miscellaneous)
    Chemistry (all)
    Biotecnología
    Astronomia / física
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