Autor según el artículo: Llaurador-Coll, M; Rios, S; García-Gavilán, JF; Babio, N; Vilella, E; Salas-Salvadó, J
Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / LLAURADOR COLL, MARTÍ / Rios Azuara, Santiago / Salas Salvadó, Jorge / Vilella Cuadrada, Elisabet
Palabras clave: Protein extension assay Predimed-plus trial Older subjects Metabolic syndrome Cognitive impairment Cholesterol Body mass index protein extension assay predimed-plus trial older subjects metabolic syndrome impairment cohort cognitive impairment brain
Resumen: Cognitive impairment is present in a broad spectrum of medical conditions and in aging. Here, we aimed to identify plasma proteins related to cognitive function in a sample of older adults with overweight/obesity and metabolic syndrome. A total of 129 subjects (mean age 64.7 years; 36% females) were grouped according to low (l-GCF, N=65) or high (h-GCF, N=64) global cognitive function and matched according to education, sex, age, and body mass index. Cognitive performance was assessed using neuropsychological tests. Plasma levels of 92 neurology-related proteins were assessed using a proximity extension assay. An elastic net regression analysis was used to identify proteins more associated with cognitive performance. Additionally, the protein expression levels were compared between the two groups by means of a t-test with false discovery rate correction. Pearson correlations were used to assess associations between the protein levels and scores from the neurocognitive tests. Six proteins (alpha-2-MRAP, HAGH, Siglec-9, MDGA1, IL12, and EDA2R) were identified as potential contributors to cognitive performance, remaining significantly increased in l-GCF compared to h-GCF participants after correction for multiple testing. Negative correlations (r= -0.23 to -0.18, i.e., lower protein levels, higher cognitive function) were found between global cognitive function and Siglec-9, NMNAT1, HAGH, LXN, gal-8, alpha-2-MRAP, IL12, PDGF-R-alpha, NAAA, EDA2R, CLEC1B, and LAT. Mini-mental state examination z scores showed the strongest correlations with protein levels, specifically negative correlations with CLEC1b, LXN, LAT, PLXNB3, NMNAT1, gal-8, HAGH, NAAA, CTSS, EZR, KYNU, MANF (r=-0.38 to -0.26) and a positive correlation with ADAM23 (r= 0.26). In summary, we identified several plasma proteins that were significantly associated with cognitive performance in older adults with obesity and metabolic syndrome, although further research is needed to replicate the results in larger samples and to include a predictive perspective.© 2023. The Author(s).
Áreas temáticas: Veterinary (miscellaneous) Geriatrics and gerontology Geriatrics & gerontology Complementary and alternative medicine Cardiology and cardiovascular medicine Aging
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jesusfrancisco.garcia@urv.cat marti.llaurador@urv.cat elisabet.vilella@urv.cat marti.llaurador@urv.cat jesusfrancisco.garcia@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0001-7095-7041 0000-0002-1887-5919 0000-0001-7095-7041 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://link.springer.com/article/10.1007/s11357-023-00764-y
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Geroscience.
Referencia de l'ítem segons les normes APA: Llaurador-Coll, M; Rios, S; García-Gavilán, JF; Babio, N; Vilella, E; Salas-Salvadó, J (2023). Plasma levels of neurology-related proteins are associated with cognitive performance in an older population with overweight/obesity and metabolic syndrome. Geroscience, (), -. DOI: 10.1007/s11357-023-00764-y
DOI del artículo: 10.1007/s11357-023-00764-y
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV