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Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS)

  • Datos identificativos

    Identificador: imarina:9296451
    Autores:
    Escobar-Morreale, HFMartínez-García, MAInsenser, MCañellas, NCorreig, XLuque-Ramírez, M
    Resumen:
    Background: The polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged the hypothesis, using state-of-the art proton nuclear magnetic resonance spectroscopy metabolomics profiling, that androgen excess in women induces also a certain masculinization of intermediate metabolism that is modulated by obesity. Methods: Participants were 53 Caucasian young adults, including 17 women with classic PCOS consisting of hyperandrogenism and ovulatory dysfunction, 17 non-hyperandrogenic women presenting with regular menses, and 19 healthy men, selected in order to be similar in terms of age and body mass index (BMI). Half of the subjects had obesity defined by a body mass index ≥ 30 kg/m2. Subjects maintained the same diet unrestricted in carbohydrates for 3 days before sampling and maintained their lifestyle and exercise patterns prior and during the study. Plasma samples were submitted to proton nuclear magnetic resonance spectroscopy metabolomics profiling. Results: Obesity associated a metabolomics profile mainly characterized by increased branched chain and aromatic aminoacids. Regardless of obesity, this unfavorable profile also characterized men as compared with control women, and was shared by women with PCOS. Notably, the negative impact of obesity on metabolomics profile was restricted to women, with obese men showing no further deterioration when compared with their non-obese counterparts. Conclusions: Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism, and masculinization of intermediate metabolism in women with PCOS, further suggesting a role for sex and sex hormones in the regulation of intermediate metabolism.
  • Otros:

    Autor según el artículo: Escobar-Morreale, HF; Martínez-García, MA; Insenser, M; Cañellas, N; Correig, X; Luque-Ramírez, M
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
    Autor/es de la URV: Cañellas Alberich, Nicolau / Correig Blanchar, Francesc Xavier
    Palabras clave: Subcutaneous adipose-tissue Sex Polycystic ovary syndrome Obesity Metabolism Estrogens Androgens sex prevalence polycystic ovary syndrome obesity obese women muscle mass metabolism mechanisms insulin-resistance glucose expression etiology estrogens androgen excess
    Resumen: Background: The polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged the hypothesis, using state-of-the art proton nuclear magnetic resonance spectroscopy metabolomics profiling, that androgen excess in women induces also a certain masculinization of intermediate metabolism that is modulated by obesity. Methods: Participants were 53 Caucasian young adults, including 17 women with classic PCOS consisting of hyperandrogenism and ovulatory dysfunction, 17 non-hyperandrogenic women presenting with regular menses, and 19 healthy men, selected in order to be similar in terms of age and body mass index (BMI). Half of the subjects had obesity defined by a body mass index ≥ 30 kg/m2. Subjects maintained the same diet unrestricted in carbohydrates for 3 days before sampling and maintained their lifestyle and exercise patterns prior and during the study. Plasma samples were submitted to proton nuclear magnetic resonance spectroscopy metabolomics profiling. Results: Obesity associated a metabolomics profile mainly characterized by increased branched chain and aromatic aminoacids. Regardless of obesity, this unfavorable profile also characterized men as compared with control women, and was shared by women with PCOS. Notably, the negative impact of obesity on metabolomics profile was restricted to women, with obese men showing no further deterioration when compared with their non-obese counterparts. Conclusions: Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism, and masculinization of intermediate metabolism in women with PCOS, further suggesting a role for sex and sex hormones in the regulation of intermediate metabolism.
    Áreas temáticas: Genetics & heredity Gender studies Endocrinology & metabolism Endocrinology Ciencias sociales Ciências biológicas ii
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: xavier.correig@urv.cat nicolau.canyellas@urv.cat
    Identificador del autor: 0000-0002-6902-3054 0000-0003-4856-8132
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://bsd.biomedcentral.com/articles/10.1186/s13293-023-00507-w
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Biology Of Sex Differences. 14 (1): 21-
    Referencia de l'ítem segons les normes APA: Escobar-Morreale, HF; Martínez-García, MA; Insenser, M; Cañellas, N; Correig, X; Luque-Ramírez, M (2023). Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS). Biology Of Sex Differences, 14(1), 21-. DOI: 10.1186/s13293-023-00507-w
    DOI del artículo: 10.1186/s13293-023-00507-w
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Endocrinology,Endocrinology & Metabolism,Gender Studies,Genetics & Heredity
    Subcutaneous adipose-tissue
    Sex
    Polycystic ovary syndrome
    Obesity
    Metabolism
    Estrogens
    Androgens
    sex
    prevalence
    polycystic ovary syndrome
    obesity
    obese women
    muscle mass
    metabolism
    mechanisms
    insulin-resistance
    glucose
    expression
    etiology
    estrogens
    androgen excess
    Genetics & heredity
    Gender studies
    Endocrinology & metabolism
    Endocrinology
    Ciencias sociales
    Ciências biológicas ii
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