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Enantioselective Catalysis with Pyrrolidinyl Gold(I) Complexes: DFT and NEST Analysis of the Chiral Binding Pocket

  • Datos identificativos

    Identificador: imarina:9322152
    Autores:
    Zuccarello, GNannini, LJArroyo-Bondía, AFincias, NArranz, IPérez-Jimeno, AHPeeters, MMartín-Torres, ISadurní, AGarcía-Vázquez, VWang, YFKirillova, MSMontesinos-Magraner, MCaniparoli, UNúñez, GMaseras, FBesora, MEscofet, IEchavarren, AM
    Resumen:
    A new generation of chiral gold(I) catalysts based on variations of complexes with JohnPhos-type ligands with a remote C2-symmetric 2,5-diarylpyrrolidine have been synthesized with different substitutions at the top and bottom aryl rings: from replacing the phosphine by a N-heterocyclic carbene (NHC) to increasing the steric hindrance with bis- or tris-biphenylphosphine scaffolds, or by directly attaching the C2-chiral pyrrolidine in the ortho-position of the dialkylphenyl phosphine. The new chiral gold(I) catalysts have been tested in the intramolecular [4+2] cycloaddition of arylalkynes with alkenes and in the atroposelective synthesis of 2-arylindoles. Interestingly, simpler catalysts with the C2-chiral pyrrolidine in the ortho-position of the dialkylphenyl phosphine led to the formation of opposite enantiomers. The chiral binding pockets of the new catalysts have been analyzed by DFT calculations. As revealed by non-covalent interaction plots, attractive non-covalent interactions between substrates and catalysts direct specific enantioselective folding. Furthermore, we have introduced the open-source tool NEST, specifically designed to account for steric effects in cylindrical-shaped complexes, which allows predicting experimental enantioselectivities in our systems.© 2023 The Authors. Published by American Chemical Society.
  • Otros:

    Autor según el artículo: Zuccarello, G; Nannini, LJ; Arroyo-Bondía, A; Fincias, N; Arranz, I; Pérez-Jimeno, AH; Peeters, M; Martín-Torres, I; Sadurní, A; García-Vázquez, V; Wang, YF; Kirillova, MS; Montesinos-Magraner, M; Caniparoli, U; Núñez, G; Maseras, F; Besora, M; Escofet, I; Echavarren, AM
    Departamento: Química Analítica i Química Orgànica
    Autor/es de la URV: Arranz De La Calle, Isabel / Arroyo Bondía, Ana / Besora Bonet, Maria / Caniparoli, Ulysse Grégoire / ECHAVARREN PABLOS, ANTONIO / Martín Torres, Inmaculada / Montesinos Magraner, Marc / Nuñez, Gonzalo Darío / Pérez Jimeno, Alba Helena / Sadurní Parera, Anna / Wang, Yufei
    Palabras clave: Nest tool Gold catalysis Enynes Enantioselective catalysis Dft calculations Atroposelective cyclization Asymmetric catalysis platinum pi phosphine nest tool ligands gold catalysis enynes dft calculations binol atroposelective cyclization arylalkynes allenamides alkenes 4+2 cycloadditions
    Resumen: A new generation of chiral gold(I) catalysts based on variations of complexes with JohnPhos-type ligands with a remote C2-symmetric 2,5-diarylpyrrolidine have been synthesized with different substitutions at the top and bottom aryl rings: from replacing the phosphine by a N-heterocyclic carbene (NHC) to increasing the steric hindrance with bis- or tris-biphenylphosphine scaffolds, or by directly attaching the C2-chiral pyrrolidine in the ortho-position of the dialkylphenyl phosphine. The new chiral gold(I) catalysts have been tested in the intramolecular [4+2] cycloaddition of arylalkynes with alkenes and in the atroposelective synthesis of 2-arylindoles. Interestingly, simpler catalysts with the C2-chiral pyrrolidine in the ortho-position of the dialkylphenyl phosphine led to the formation of opposite enantiomers. The chiral binding pockets of the new catalysts have been analyzed by DFT calculations. As revealed by non-covalent interaction plots, attractive non-covalent interactions between substrates and catalysts direct specific enantioselective folding. Furthermore, we have introduced the open-source tool NEST, specifically designed to account for steric effects in cylindrical-shaped complexes, which allows predicting experimental enantioselectivities in our systems.© 2023 The Authors. Published by American Chemical Society.
    Áreas temáticas: Physical and theoretical chemistry Organic chemistry Chemistry, multidisciplinary Chemistry (miscellaneous) Analytical chemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: anna.sadurni@urv.cat antoniomaria.echavarren@urv.cat maria.besora@urv.cat yufei.wang@estudiants.urv.cat albahelena.perez@estudiants.urv.cat inmaculada.martin@estudiants.urv.cat ulysse.caniparoli@estudiants.urv.cat ana.arroyo@estudiants.urv.cat isabel.arranz@estudiants.urv.cat
    Identificador del autor: 0000-0002-6418-7930 0000-0002-6656-5827
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://pubs.acs.org/doi/10.1021/jacsau.3c00159
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Jacs Au. 3 (6): 1742-1754
    Referencia de l'ítem segons les normes APA: Zuccarello, G; Nannini, LJ; Arroyo-Bondía, A; Fincias, N; Arranz, I; Pérez-Jimeno, AH; Peeters, M; Martín-Torres, I; Sadurní, A; García-Vázquez, V; Wa (2023). Enantioselective Catalysis with Pyrrolidinyl Gold(I) Complexes: DFT and NEST Analysis of the Chiral Binding Pocket. Jacs Au, 3(6), 1742-1754. DOI: 10.1021/jacsau.3c00159
    DOI del artículo: 10.1021/jacsau.3c00159
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Analytical Chemistry,Chemistry (Miscellaneous),Chemistry, Multidisciplinary,Organic Chemistry,Physical and Theoretical Chemistry
    Nest tool
    Gold catalysis
    Enynes
    Enantioselective catalysis
    Dft calculations
    Atroposelective cyclization
    Asymmetric catalysis
    platinum
    pi
    phosphine
    nest tool
    ligands
    gold catalysis
    enynes
    dft calculations
    binol
    atroposelective cyclization
    arylalkynes
    allenamides
    alkenes
    4+2 cycloadditions
    Physical and theoretical chemistry
    Organic chemistry
    Chemistry, multidisciplinary
    Chemistry (miscellaneous)
    Analytical chemistry
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