Autor según el artículo: Soliz-Rueda, JR; López-Fernández-Sobrino, R; Torres-Fuentes, C; Bravo, FI; Suárez, M; Mulero, M; Muguerza, B
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Bravo Vázquez, Francisca Isabel / López Fernández, Raul / Muguerza Marquínez, Maria Begoña / Mulero Abellán, Miguel / Soliz Rueda, Jorge Ricardo / Suárez Recio, Manuel / Torres Fuentes, Cristina
Palabras clave: Circadian clock system rhythms proanthocyanidins nitric-oxide metabolomics melatonin expression cafeteria diet blood-pressure
Resumen: Changes in light/dark cycles and obesogenic diets are related to the disruption of circadian rhythms and metabolic disorders. Grape seed flavanols have shown beneficial effects on metabolic diseases and, recently, a circadian system modulation has been suggested to mediate their health-enhancing properties. Therefore, the aim of this study was to evaluate the grape seed (poly)phenol extract (GSPE) effects in healthy and obese rats after a light/dark cycle disruption. Forty-eight rats were fed a standard (STD) or cafeteria (CAF) diet for 6 weeks under STD conditions of a light/dark cycle (12 h light per day, L12). Then, animals were switched to a long (18 h light per day, L18) or short (6 h light per day, L6) photoperiod and administered a vehicle (VH) or GSPE (25 mg kg-1) for 1 week. The results showed changes in serum lipids and insulin and metabolomic profiles dependent on the photoperiod and animal health status. GSPE administration improved serum parameters and increased the Nampt gene expression in CAF rats and modified the metabolomic profile in a photoperiod-dependent manner. Metabolic effects of light/dark disturbance depend on the health status of the rats, with diet-induced CAF-induced obese rats being more affected. Grape seed flavanols improve the metabolic status in a photoperiod-dependent manner and their effects on the circadian system suggest that part of their metabolic effects could be mediated by their action on biological rhythms.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: franciscaisabel.bravo@urv.cat jorgericardo.solizr@urv.cat jorgericardo.solizr@urv.cat manuel.suarez@urv.cat miquel.mulero@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat
Identificador del autor: 0000-0002-6468-3088 0000-0003-0122-8253 0000-0001-7384-8588 0000-0002-2917-6910
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo00260h
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food & Function. 14 (14): 6443-6454
Referencia de l'ítem segons les normes APA: Soliz-Rueda, JR; López-Fernández-Sobrino, R; Torres-Fuentes, C; Bravo, FI; Suárez, M; Mulero, M; Muguerza, B (2023). Metabolism disturbance by light/dark cycle switching depends on the rat health status: the role of grape seed flavanols. Food & Function, 14(14), 6443-6454. DOI: 10.1039/d3fo00260h
DOI del artículo: 10.1039/d3fo00260h
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV