Autor según el artículo: Arreaza-Gil, V; Palacios-Jordan, H; Romero, MD; Torres-Fuentes, C; Rodriguez, MA; Remesar, X; Fernandez-López, JA; Arola-Arnal, A
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Arola Arnal, Anna / Arreaza Gil, Verónica / Rodríguez Merayo, María Araceli / Torres Fuentes, Cristina
Palabras clave: Circadian-rhythms tryptophan-metabolism polyphenols plasma mechanisms healthy gut microbiota gender-differences expression clock
Resumen: Proanthocyanidins (PAs) are one of the most commonly ingested polyphenols in the human diet, with a wide range of beneficial health effects. Remarkably, PAs have been reported to influence core and peripheral clock genes expression, and their effects may change in a time-of-day dependent manner. Therefore, the aim of this study was to investigate whether the capacity of PAs to modulate the metabolome is conditioned by the time-of-day in which these compounds are consumed in a diet- and sex-dependent manner. To do this, a grape seed proanthocyanidin extract (GSPE) was administered to female and male Fischer 344 rats at ZT0 (in the morning) and ZT12 (at night) and the GSPE administration time effect was evaluated on clock genes expression, melatonin hormone and serum metabolite levels in a healthy and obesogenic context. The results showed an administration time effect of GSPE on the metabolome in a sex and diet-dependent manner. Specifically, there was an effect on amino acid, lipid and cholate metabolite levels that correlated with the central clock genes expression. Therefore, this study shows a strong influence of sex and diet on the PAs effects on the metabolome, modulated in turn by the time-of-day.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: cristina.torres@urv.cat araceli.rodriguez@urv.cat araceli.rodriguez@urv.cat anna.arola@urv.cat veronica.arreaza@estudiants.urv.cat veronica.arreaza@estudiants.urv.cat
Identificador del autor: 0000-0002-2917-6910 0000-0002-9456-6528 0000-0002-9456-6528 0000-0001-6529-1345 0000-0002-8301-2095 0000-0002-8301-2095
Fecha de alta del registro: 2024-05-23
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo01551c
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food & Function. 14 (15): 6941-6956
Referencia de l'ítem segons les normes APA: Arreaza-Gil, V; Palacios-Jordan, H; Romero, MD; Torres-Fuentes, C; Rodriguez, MA; Remesar, X; Fernandez-López, JA; Arola-Arnal, A (2023). Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent. Food & Function, 14(15), 6941-6956. DOI: 10.1039/d3fo01551c
DOI del artículo: 10.1039/d3fo01551c
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV