Autor según el artículo: Atzeni, A; Nishi, SK; Babio, N; Belzer, C; Konstanti, P; Vioque, J; Corella, D; Castañer, O; Vidal, J; Moreno-Indias, I; Torres-Collado, L; Asensio, EM; Fitó, M; Gomez-Perez, AM; Arias, A; Ruiz-Canela, M; Hu, FB; Tinahones, FJ; Salas-Salvadó, J
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / Nishi, Stephanie Kimiko / Salas Salvadó, Jorge
Palabras clave: Mediterranean diet Mediterranean cohort Fecal microbiota Cardiovascular disease Carbohydrate quality validity population obesity mediterranean diet fecal microbiota cardiovascular disease association
Resumen: The impact of carbohydrate quality, measured by the carbohydrate quality index (CQI), on gut microbiota and health has been scarcely investigated. The aim of this study was to cross-sectionally and longitudinally explore the relationships between CQI, fecal microbiota, and cardiometabolic risk factors in an elderly Mediterranean population at high cardiovascular risk. At baseline and 1-year, CQI was assessed from food frequency questionnaires data, cardiometabolic risk factors were measured, and fecal microbiota profiled from 16S sequencing. Multivariable-adjusted linear regression models were fitted to assess the associations between tertiles of baseline CQI, fecal microbiota, and cardiometabolic risk factors at baseline, and between tertiles of 1-year change in CQI, 1-year change in fecal microbiota and cardiometabolic risk factors. Cross-sectionally, higher CQI was positively associated with Shannon alpha diversity index, and abundance of genera Faecalibacterium and Christensenellaceae R7 group, and negatively associated with the abundance of Odoribacter, and uncultured Rhodospirillales genera. Some of these genera were associated with higher glycated hemoglobin and lower body mass index. In addition, we observed a positive association between CQI, and some pathways related with the metabolism of butyrate precursors and plants-origin molecules. Longitudinally, 1-year improvement in CQI was associated with a concurrent increase in the abundance of genera Butyrivibrio. Increased abundance of this genera was associated with 1-year improvement in insulin status. These observations suggest that a better quality of carbohydrate intake is associated with improved metabolic health, and this improvement could be modulated by greater alpha diversity and abundance of specific genera linked to beneficial metabolic outcomes.
Áreas temáticas: Microbiology (medical) Microbiology Medicina veterinaria Medicina i Infectious diseases Gastroenterology & hepatology Gastroenterology Ciências biológicas iii Ciências biológicas i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: stephanie.nishi@urv.cat alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2246185
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Gut Microbes. 15 (2): 2246185-2246185
Referencia de l'ítem segons les normes APA: Atzeni, A; Nishi, SK; Babio, N; Belzer, C; Konstanti, P; Vioque, J; Corella, D; Castañer, O; Vidal, J; Moreno-Indias, I; Torres-Collado, L; Asensio, E (2023). Carbohydrate quality, fecal microbiota and cardiometabolic health in older adults: a cohort study. Gut Microbes, 15(2), 2246185-2246185. DOI: 10.1080/19490976.2023.2246185
DOI del artículo: 10.1080/19490976.2023.2246185
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV