Articles producció científica> Medicina i Cirurgia

Lipoprotein profile assessed by 1H NMR, BMI and blood pressure are associated with vascular alterations in children with familial hypercholesterolaemia

  • Datos identificativos

    Identificador: imarina:9330093
    Autores:
    Llop, DFeliu, AIbarretxe, DEscribano, JPlana, NBorjabad-Rodriguez, CMasana, LVallve, J C
    Resumen:
    Children with familial hypercholesterolaemia (FH) have elevated low-density lipoprotein cholesterol (LDL-C) concentrations since birth, which increases the risk of cardiovascular disease in adulthood. Arterial injury and stiffness parameters, including carotid intima media thickness (cIMT), pulse wave velocity (PWV) and distensibility (DIST), can be detected early in childhood. We studied the associations between cIMT, PWV and DIST with the lipoprotein profile assessed by proton nuclear magnetic resonance (1H NMR) and with influential variables such as blood pressure (BP) or body mass index (BMI) in children with FH.In this cross-sectional study, we included 201 children (96 with FH and 105 non-FH controls). Clinical history, physical examination and standard biochemical studies were performed. FH genetic testing was performed when clinically indicated. Carotid ultrasonography and an advanced lipoprotein profile by 1H NMR were performed. Multivariate and classification methods were used. There were no differences between cIMT, PWV and DIST between FH and non-FH children. FH children presented more total LDL and large, medium and small particles. Small LDL particles, BMI and systolic BP determined the presence of pathological IMT in the FH group. LDL size, high-density lipoproteins and very low-density lipoprotein particles together with blood pressure determined the presence of pathological arterial wall elasticity.Alterations in lipoprotein parameters assessed by are associated with early structural and functional arterial characteristics in children with FH. BMI and BP act as boosting factors. Cardiovascular prevention should start early in children with FH, encompassing all components of a healthy lifestyle.Copyright © 2023 The Author(s). Published by Elsevier B.V. A
  • Otros:

    Autor según el artículo: Llop, D; Feliu, A; Ibarretxe, D; Escribano, J; Plana, N; Borjabad-Rodriguez, C; Masana, L; Vallve, J C
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Escribano Subías, Joaquín / Feliu Rovira, Albert / Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia / Vallvé Torrente, Joan Carles
    Palabras clave: Risk factors Pulse wave analysis Proton magnetic resonance spectroscopy Lipoprotein profile Intima-media thickness Hyperlipoproteinemia type ii Humans Familiar hypercholesterolemia Familiar hyper Cross-sectional studies Cholesterol, ldl Children Child Carotid intima-media thickness Body mass index Blood pressure Arterial stiffness Arterial injury susceptibility subclinical atherosclerosis size pulse-wave velocity particle number low-density-lipoprotein lipoprotein pro file disease children cardiovascular risk arterial stiffness arterial injury
    Resumen: Children with familial hypercholesterolaemia (FH) have elevated low-density lipoprotein cholesterol (LDL-C) concentrations since birth, which increases the risk of cardiovascular disease in adulthood. Arterial injury and stiffness parameters, including carotid intima media thickness (cIMT), pulse wave velocity (PWV) and distensibility (DIST), can be detected early in childhood. We studied the associations between cIMT, PWV and DIST with the lipoprotein profile assessed by proton nuclear magnetic resonance (1H NMR) and with influential variables such as blood pressure (BP) or body mass index (BMI) in children with FH.In this cross-sectional study, we included 201 children (96 with FH and 105 non-FH controls). Clinical history, physical examination and standard biochemical studies were performed. FH genetic testing was performed when clinically indicated. Carotid ultrasonography and an advanced lipoprotein profile by 1H NMR were performed. Multivariate and classification methods were used. There were no differences between cIMT, PWV and DIST between FH and non-FH children. FH children presented more total LDL and large, medium and small particles. Small LDL particles, BMI and systolic BP determined the presence of pathological IMT in the FH group. LDL size, high-density lipoproteins and very low-density lipoprotein particles together with blood pressure determined the presence of pathological arterial wall elasticity.Alterations in lipoprotein parameters assessed by are associated with early structural and functional arterial characteristics in children with FH. BMI and BP act as boosting factors. Cardiovascular prevention should start early in children with FH, encompassing all components of a healthy lifestyle.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
    Áreas temáticas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: daiana.ibarretxe@urv.cat luis.masana@urv.cat didac.llop@urv.cat celia.rodriguez@urv.cat jc.vallve@urv.cat albert.feliu@urv.cat didac.llop@urv.cat celia.rodriguez@urv.cat jc.vallve@urv.cat joaquin.escribano@urv.cat
    Identificador del autor: 0000-0002-0789-4954 0000-0001-8160-3716 0000-0001-8160-3716 0000-0002-5041-459X
    Fecha de alta del registro: 2024-08-10
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.nmcd-journal.com/article/S0939-4753(23)00245-4/fulltext#%20
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nutrition Metabolism And Cardiovascular Diseases. 33 (10): 2035-2043
    Referencia de l'ítem segons les normes APA: Llop, D; Feliu, A; Ibarretxe, D; Escribano, J; Plana, N; Borjabad-Rodriguez, C; Masana, L; Vallve, J C (2023). Lipoprotein profile assessed by 1H NMR, BMI and blood pressure are associated with vascular alterations in children with familial hypercholesterolaemia. Nutrition Metabolism And Cardiovascular Diseases, 33(10), 2035-2043. DOI: 10.1016/j.numecd.2023.06.012
    DOI del artículo: 10.1016/j.numecd.2023.06.012
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Risk factors
    Pulse wave analysis
    Proton magnetic resonance spectroscopy
    Lipoprotein profile
    Intima-media thickness
    Hyperlipoproteinemia type ii
    Humans
    Familiar hypercholesterolemia
    Familiar hyper
    Cross-sectional studies
    Cholesterol, ldl
    Children
    Child
    Carotid intima-media thickness
    Body mass index
    Blood pressure
    Arterial stiffness
    Arterial injury
    susceptibility
    subclinical atherosclerosis
    size
    pulse-wave velocity
    particle number
    low-density-lipoprotein
    lipoprotein pro file
    disease
    children
    cardiovascular risk
    arterial stiffness
    arterial injury
    Serviço social
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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