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Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study

  • Datos identificativos

    Identificador: imarina:9331786
    Autores:
    Cruz-Rodríguez, JCanals-Sans, JHernández-Martínez, CVoltas-Moreso, NArija, V
    Resumen:
    Maternal vitamin B12 deficiency has been associated with disturbed cognitive functioning in offspring at different ages during childhood. However, this association has not been explored in pre-school-age children. The objective of this study was to examine the association between maternal vitamin B12 levels at the beginning and end of pregnancy and cognitive functioning in their children at 4 years of age. This longitudinal prospective study included a subsample of pregnant women and their children aged 4 years (n = 249) who participated in the ECLIPSES Study conducted in the province of Tarragona, Spain, from 2013 to 2017. Maternal vitamin B12 concentrations were determined in the first and third trimesters, and sociodemographic, nutritional and psychological data were collected. The children's cognitive functioning was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) and subtests of the Neuropsychological Assessment of Development (NEPSY-II). The multivariable models showed a significant relationship between vitamin B12 and the working memory index in the first trimester of the pregnancy but not in the third trimester. Children of mothers in the second vitamin B12 level tertile (314-413 pg/mL) (β = 6.468, 95% confidence interval [CI]: = 2.054, 10.882, p = 0.004) and third vitamin B12 level tertile (≥414 pg/mL) (β = 4.703, 95% CI: = 0.292, 9.114, p = 0.037) scored higher in the working memory index of the WPPSI-IV than the children of mothers with vitamin B12 levels in the first tertile (<314 pg/mL). Maintaining an adequate level of maternal vitamin B12 during early pregnancy contributes to improved performance in childhood working memory at 4 years of age.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Lt
  • Otros:

    Autor según el artículo: Cruz-Rodríguez, J; Canals-Sans, J; Hernández-Martínez, C; Voltas-Moreso, N; Arija, V
    Departamento: Psicologia
    Autor/es de la URV: Arija Val, Maria Victoria / Canals Sans, Josefa / Cruz Rodríguez, Josue / Hernandez Martinez, Carmen / Voltas Moreso, Núria
    Palabras clave: Vitamin b12 levels Prenatal nutrition Pregnancy Folate-deficiency Eclipses study Cognitive functioning Children's health Child development working-memory women vitamin b12 levels questionnaire prenatal nutrition pregnancy nutrition neurodevelopment infant eclipses study cognitive functioning children's health brain-development
    Resumen: Maternal vitamin B12 deficiency has been associated with disturbed cognitive functioning in offspring at different ages during childhood. However, this association has not been explored in pre-school-age children. The objective of this study was to examine the association between maternal vitamin B12 levels at the beginning and end of pregnancy and cognitive functioning in their children at 4 years of age. This longitudinal prospective study included a subsample of pregnant women and their children aged 4 years (n = 249) who participated in the ECLIPSES Study conducted in the province of Tarragona, Spain, from 2013 to 2017. Maternal vitamin B12 concentrations were determined in the first and third trimesters, and sociodemographic, nutritional and psychological data were collected. The children's cognitive functioning was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) and subtests of the Neuropsychological Assessment of Development (NEPSY-II). The multivariable models showed a significant relationship between vitamin B12 and the working memory index in the first trimester of the pregnancy but not in the third trimester. Children of mothers in the second vitamin B12 level tertile (314-413 pg/mL) (β = 6.468, 95% confidence interval [CI]: = 2.054, 10.882, p = 0.004) and third vitamin B12 level tertile (≥414 pg/mL) (β = 4.703, 95% CI: = 0.292, 9.114, p = 0.037) scored higher in the working memory index of the WPPSI-IV than the children of mothers with vitamin B12 levels in the first tertile (<314 pg/mL). Maintaining an adequate level of maternal vitamin B12 during early pregnancy contributes to improved performance in childhood working memory at 4 years of age.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.
    Áreas temáticas: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Obstetrics and gynecology Nutrition and dietetics Nutrition & dietetics Nutrição Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: nuria.voltas@urv.cat josue.cruz@estudiants.urv.cat carmen.hernandez@urv.cat josefa.canals@urv.cat victoria.arija@urv.cat
    Identificador del autor: 0000-0001-8855-0282 0000-0001-6328-8679 0000-0002-6209-9558 0000-0002-1758-0975
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.13580
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Maternal And Child Nutrition. 20 (1): e13580-e13580
    Referencia de l'ítem segons les normes APA: Cruz-Rodríguez, J; Canals-Sans, J; Hernández-Martínez, C; Voltas-Moreso, N; Arija, V (2024). Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study. Maternal And Child Nutrition, 20(1), e13580-e13580. DOI: 10.1111/mcn.13580
    DOI del artículo: 10.1111/mcn.13580
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2024
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Nutrition & Dietetics,Nutrition and Dietetics,Obstetrics and Gynecology,Pediatrics,Pediatrics, Perinatology and Child Health,Public Health, Environmental and Occupational Health
    Vitamin b12 levels
    Prenatal nutrition
    Pregnancy
    Folate-deficiency
    Eclipses study
    Cognitive functioning
    Children's health
    Child development
    working-memory
    women
    vitamin b12 levels
    questionnaire
    prenatal nutrition
    pregnancy
    nutrition
    neurodevelopment
    infant
    eclipses study
    cognitive functioning
    children's health
    brain-development
    Saúde coletiva
    Public health, environmental and occupational health
    Pediatrics, perinatology and child health
    Pediatrics
    Obstetrics and gynecology
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Enfermagem
    Ciências biológicas ii
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