Autor según el artículo: Cruz-Rodríguez, J; Canals-Sans, J; Hernández-Martínez, C; Voltas-Moreso, N; Arija, V
Departamento: Psicologia
Autor/es de la URV: Arija Val, Maria Victoria / Canals Sans, Josefa / Cruz Rodríguez, Josue / Hernandez Martinez, Carmen / Voltas Moreso, Núria
Palabras clave: Vitamin b12 levels Prenatal nutrition Pregnancy Folate-deficiency Eclipses study Cognitive functioning Children's health Child development working-memory women vitamin b12 levels questionnaire prenatal nutrition pregnancy nutrition neurodevelopment infant eclipses study cognitive functioning children's health brain-development
Resumen: Maternal vitamin B12 deficiency has been associated with disturbed cognitive functioning in offspring at different ages during childhood. However, this association has not been explored in pre-school-age children. The objective of this study was to examine the association between maternal vitamin B12 levels at the beginning and end of pregnancy and cognitive functioning in their children at 4 years of age. This longitudinal prospective study included a subsample of pregnant women and their children aged 4 years (n = 249) who participated in the ECLIPSES Study conducted in the province of Tarragona, Spain, from 2013 to 2017. Maternal vitamin B12 concentrations were determined in the first and third trimesters, and sociodemographic, nutritional and psychological data were collected. The children's cognitive functioning was assessed using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-IV) and subtests of the Neuropsychological Assessment of Development (NEPSY-II). The multivariable models showed a significant relationship between vitamin B12 and the working memory index in the first trimester of the pregnancy but not in the third trimester. Children of mothers in the second vitamin B12 level tertile (314-413 pg/mL) (β = 6.468, 95% confidence interval [CI]: = 2.054, 10.882, p = 0.004) and third vitamin B12 level tertile (≥414 pg/mL) (β = 4.703, 95% CI: = 0.292, 9.114, p = 0.037) scored higher in the working memory index of the WPPSI-IV than the children of mothers with vitamin B12 levels in the first tertile (<314 pg/mL). Maintaining an adequate level of maternal vitamin B12 during early pregnancy contributes to improved performance in childhood working memory at 4 years of age.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.
Áreas temáticas: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Obstetrics and gynecology Nutrition and dietetics Nutrition & dietetics Nutrição Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: nuria.voltas@urv.cat victoria.arija@urv.cat josefa.canals@urv.cat carmen.hernandez@urv.cat josue.cruz@estudiants.urv.cat
Identificador del autor: 0000-0001-8855-0282 0000-0002-1758-0975 0000-0002-6209-9558 0000-0001-6328-8679
Fecha de alta del registro: 2024-01-13
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.13580
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Maternal And Child Nutrition. 20 (1): e13580-e13580
Referencia de l'ítem segons les normes APA: Cruz-Rodríguez, J; Canals-Sans, J; Hernández-Martínez, C; Voltas-Moreso, N; Arija, V (2024). Prenatal vitamin B12 status and cognitive functioning in children at 4 years of age: The ECLIPSES Study. Maternal And Child Nutrition, 20(1), e13580-e13580. DOI: 10.1111/mcn.13580
DOI del artículo: 10.1111/mcn.13580
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV