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Prenatal iron supplementation adjusted to maternal iron stores reduces behavioural problems in 4-year-old children

  • Datos identificativos

    Identificador: imarina:9332396
    Autores:
    Iglesias-Vázquez, LCanals, JHernández-Martínez, CVoltas, NArija, V
    Resumen:
    Prenatal iron supplementation improves children's health and cognitive performance, but few studies explore behavioural development. This study assessed the effects of adjusting prenatal iron supplementation to maternal iron stores during early pregnancy on children's behavioural problems. Randomized controlled trial conducted in Tarragona (Spain) involving 230 nonanaemic pregnant women and their children after a 4-year follow-up. Based on haemoglobin (Hb) levels before gestational week (GW) 12, women receive different iron doses: those with Hb = 110-130 g/L were randomized to receive 80 or 40 mg/day and those with Hb > 130 g/L were randomized to receive 20 or 40 mg/day. Maternal iron stores at GW12 were classified using serum ferritin (SF) as low (SF < 15 µg/L), normal (SF = 15-65 µg/L), and normal-high (SF > 65 µg/L). Children's behaviour was assessed by parents using the Child Behaviour Checklist for ages 1.5-5 years and the Behaviour Rating Inventory of Executive Function-Preschool Version, and by teachers using the Teacher's Report Form for ages 1.5-5 years. Multivariable regression models were performed. Taking 80 mg/day of iron improved child behaviour when women had low iron stores but worsened it when mothers had normal-high iron stores, except for depressive and attention/hyperactivity problems. Taking 20 mg/day of iron improved behaviour only in those children whose mothers had SF > 65 µg/L in early pregnancy. Additionally, executive functioning improved at high doses of prenatal iron when maternal baseline SF < 15 µg/L. Adjusting prenatal iron supplementation to both maternal baseline Hb levels and iron stores reduces behavioural problems in 4-year-old children.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.
  • Otros:

    Autor según el artículo: Iglesias-Vázquez, L; Canals, J; Hernández-Martínez, C; Voltas, N; Arija, V
    Departamento: Ciències Mèdiques Bàsiques Psicologia
    Autor/es de la URV: Arija Val, Maria Victoria / Canals Sans, Josefa / Hernandez Martinez, Carmen / Iglesias Vazquez, Lucia / Voltas Moreso, Núria
    Palabras clave: Term-follow-up Pregnancy Iron supplementation Executive functioning Child behaviour Behavioural problems temperament risk pregnancy nutrition iron supplementation hemoglobin executive functioning environment deficiency consequences child behaviour brain-development
    Resumen: Prenatal iron supplementation improves children's health and cognitive performance, but few studies explore behavioural development. This study assessed the effects of adjusting prenatal iron supplementation to maternal iron stores during early pregnancy on children's behavioural problems. Randomized controlled trial conducted in Tarragona (Spain) involving 230 nonanaemic pregnant women and their children after a 4-year follow-up. Based on haemoglobin (Hb) levels before gestational week (GW) 12, women receive different iron doses: those with Hb = 110-130 g/L were randomized to receive 80 or 40 mg/day and those with Hb > 130 g/L were randomized to receive 20 or 40 mg/day. Maternal iron stores at GW12 were classified using serum ferritin (SF) as low (SF < 15 µg/L), normal (SF = 15-65 µg/L), and normal-high (SF > 65 µg/L). Children's behaviour was assessed by parents using the Child Behaviour Checklist for ages 1.5-5 years and the Behaviour Rating Inventory of Executive Function-Preschool Version, and by teachers using the Teacher's Report Form for ages 1.5-5 years. Multivariable regression models were performed. Taking 80 mg/day of iron improved child behaviour when women had low iron stores but worsened it when mothers had normal-high iron stores, except for depressive and attention/hyperactivity problems. Taking 20 mg/day of iron improved behaviour only in those children whose mothers had SF > 65 µg/L in early pregnancy. Additionally, executive functioning improved at high doses of prenatal iron when maternal baseline SF < 15 µg/L. Adjusting prenatal iron supplementation to both maternal baseline Hb levels and iron stores reduces behavioural problems in 4-year-old children.© 2023 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.
    Áreas temáticas: Saúde coletiva Public health, environmental and occupational health Pediatrics, perinatology and child health Pediatrics Obstetrics and gynecology Nutrition and dietetics Nutrition & dietetics Nutrição Medicina ii Medicina i General medicine Farmacia Enfermagem Ciências biológicas ii
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: nuria.voltas@urv.cat lucia.iglesias@urv.cat carmen.hernandez@urv.cat josefa.canals@urv.cat victoria.arija@urv.cat
    Identificador del autor: 0000-0001-8855-0282 0000-0001-7131-4144 0000-0001-6328-8679 0000-0002-6209-9558 0000-0002-1758-0975
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1111/mcn.13595
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Maternal And Child Nutrition. 20 (1): e13595-e13595
    Referencia de l'ítem segons les normes APA: Iglesias-Vázquez, L; Canals, J; Hernández-Martínez, C; Voltas, N; Arija, V (2024). Prenatal iron supplementation adjusted to maternal iron stores reduces behavioural problems in 4-year-old children. Maternal And Child Nutrition, 20(1), e13595-e13595. DOI: 10.1111/mcn.13595
    DOI del artículo: 10.1111/mcn.13595
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2024
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Nutrition & Dietetics,Nutrition and Dietetics,Obstetrics and Gynecology,Pediatrics,Pediatrics, Perinatology and Child Health,Public Health, Environmental and Occupational Health
    Term-follow-up
    Pregnancy
    Iron supplementation
    Executive functioning
    Child behaviour
    Behavioural problems
    temperament
    risk
    pregnancy
    nutrition
    iron supplementation
    hemoglobin
    executive functioning
    environment
    deficiency
    consequences
    child behaviour
    brain-development
    Saúde coletiva
    Public health, environmental and occupational health
    Pediatrics, perinatology and child health
    Pediatrics
    Obstetrics and gynecology
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina ii
    Medicina i
    General medicine
    Farmacia
    Enfermagem
    Ciências biológicas ii
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