Autor según el artículo: Johansen, MO; Moreno-Vedia, J; Balling, M; Smith, GD; Nordestgaard, BG
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Moreno Vedia, Juan
Palabras clave: Statement Risk Postprandial lipemia Postprandial Plasma Nonfasting triglycerides Myocardial-infarction Lipoprotein subfractions Lipoprotein cholesterol Lipids Lipid profile General population Cardiovascular-disease Cardiovascular disease Apolipoproteins
Resumen: Background and aims: During fat tolerance tests, plasma triglycerides increase while high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and intermediate-density lipoprotein (IDL) cholesterol decrease. However, it is unknown whether triglyceride content increases and cholesterol content decreases in HDL and LDL + IDL fractions following normal meals in the general population. Therefore, we tested the hypothesis that triglyceride content increases while cholesterol content decreases in HDL and LDL + IDL fractions following normal meals.Methods: In this cross-sectional study, we included 25,656 individuals aged 20-100 years, all without lipid lowering therapy at examination and selected for metabolomic profiling from the Copenhagen General Population Study. Triglyceride and cholesterol content of 14 lipoprotein fractions weas measured using nuclear magnetic resonance (NMR) spectroscopy. Time since last meal was recorded by the examiner immediately before blood sampling. Results: Following normal meals in age and sex-adjusted analyses and when compared with fasting levels, plasma triglycerides were higher for up to 5-6 h, and triglyceride content was higher for up to 6-7 h in HDL fractions, for up to 6-7 h in LDL + IDL fractions, and for up to 5-6 h in very-low-density lipoprotein (VLDL) fractions. Further, plasma cholesterol was lower for up to 2-3 h, and cholesterol content was lower for up to 0-1 h in HDL fractions and for up to 4-5 h in LDL + IDL fractions, while cholesterol content was higher for up to 4-5 h in VLDL fractions.Conclusions: Following normal meals, triglyceride content increases while cholesterol content decreases in HDL and LDL + IDL fractions.
Áreas temáticas: Saúde coletiva Psicología Peripheral vascular disease Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Antropologia / arqueologia
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: juan.moreno@estudiants.urv.cat juan.moreno@estudiants.urv.cat
Identificador del autor: 0000-0002-2673-3822 0000-0002-2673-3822
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.atherosclerosis-journal.com/article/S0021-9150(23)05237-1/fulltext#%20
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Atherosclerosis. 383
Referencia de l'ítem segons les normes APA: Johansen, MO; Moreno-Vedia, J; Balling, M; Smith, GD; Nordestgaard, BG (2023). Triglyceride content increases while cholesterol content decreases in HDL and LDL plus IDL fractions following normal meals: The Copenhagen General Population Study of 25,656 individuals. Atherosclerosis, 383(), -. DOI: 10.1016/j.atherosclerosis.2023.117316
DOI del artículo: 10.1016/j.atherosclerosis.2023.117316
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications