Autor según el artículo: Fernández-Veledo, S; Marsal-Beltran, A; Vendrell, J
Departamento: Medicina i Cirurgia Ciències Mèdiques Bàsiques
Autor/es de la URV: Fernandez Veledo, Sonia / MARSAL BELTRAN, ANNA / Vendrell Ortega, Juan José
Palabras clave: Type 2 diabetes Type 1 diabetes Sucnr1 Succinate Review Receptor gpr91 Nafld Microbiota Gestational diabetes Diabetic retinopathy Diabetic nephropathy vegf release type 2 diabetes type 1 diabetes sucnr1 succinate signal review renin release obesity nafld microbiota metabolism improvement high glucose gestational diabetes diabetic retinopathy cells antagonist
Resumen: Beyond their conventional roles in intracellular energy production, some traditional metabolites also function as extracellular messengers that activate cell-surface G-protein-coupled receptors (GPCRs) akin to hormones and neurotransmitters. These signalling metabolites, often derived from nutrients, the gut microbiota or the host's intermediary metabolism, are now acknowledged as key regulators of various metabolic and immune responses. This review delves into the multi-dimensional aspects of succinate, a dual metabolite with roots in both the mitochondria and microbiome. It also connects the dots between succinate's role in the Krebs cycle, mitochondrial respiration, and its double-edge function as a signalling transmitter within and outside the cell. We aim to provide an overview of the role of the succinate-succinate receptor 1 (SUCNR1) axis in diabetes, discussing the potential use of succinate as a biomarker and the novel prospect of targeting SUCNR1 to manage complications associated with diabetes. We further propose strategies to manipulate the succinate-SUCNR1 axis for better diabetes management; this includes pharmacological modulation of SUCNR1 and innovative approaches to manage succinate concentrations, such as succinate administration and indirect strategies, like microbiota modulation. The dual nature of succinate, both in terms of origins and roles, offers a rich landscape for understanding the intricate connections within metabolic diseases, like diabetes, and indicates promising pathways for developing new therapeutic strategies.© 2024. The Author(s).
Áreas temáticas: Saúde coletiva Química Medicina veterinaria Medicina i Internal medicine Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: anna.marsal@urv.cat sonia.fernandez@urv.cat anna.marsal@urv.cat juanjose.vendrell@urv.cat
Identificador del autor: 0000-0003-2906-3788 0000-0002-6994-6115
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://link.springer.com/article/10.1007/s00125-023-06063-7
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Diabetologia. 67 (3): 430-
Referencia de l'ítem segons les normes APA: Fernández-Veledo, S; Marsal-Beltran, A; Vendrell, J (2024). Type 2 diabetes and succinate: unmasking an age-old molecule. Diabetologia, 67(3), 430-. DOI: 10.1007/s00125-023-06063-7
DOI del artículo: 10.1007/s00125-023-06063-7
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications