Autor según el artículo: Casares-Jimenez, M; Rivero-Juarez, A; Lopez-Lopez, P; Montes, ML; Navarro-Soler, R; Peraire, J; Espinosa, N; Alemán-Valls, MR; Garcia-Garcia, T; Caballero-Gomez, J; Corona-Mata, D; Perez-Valero, I; Ulrich, RG; Rivero, A
Departamento: Medicina i Cirurgia
Autor/es de la URV: Peraire Forner, José Joaquin
Palabras clave: acute hepatitis hiv public health rat hepatitis e virus wild zoonoses Acute hepatitis Hepatitis e Hiv Infection Public health Rat hepatitis e virus Zoonoses
Resumen: Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species Paslahepevirus balayani), and consequently this group may constitute a high-risk population. We aimed to evaluate the prevalence of ratHEV by measuring viral RNA and specific IgG antibodies in a large Spanish cohort of PLWH. Multicentre study conducted in Spain evaluating PLWHIV included in the Spanish AIDS Research Network (CoRIS). Patients were evaluated for ratHEV infection using PCR at baseline and anti-ratHEV IgG by dot blot analysis to evaluate exposure to ratHEV strains. Patients with detectable ratHEV RNA were followed-up to evaluate persistence of viremia and IgG seroconversion. Eight-hundred and forty-two individuals were tested. A total of 9 individuals showed specific IgG antibodies against ratHEV, supposing a prevalence of 1.1 (95% CI; 0.5%−2.1%). Of these, only one was reactive to HEV IgG antibodies by ELISA. One sample was positive for ratHEV RNA (prevalence of infection: 0.1%; 95% CI: 0.08%−0.7%). The case was a man who had sex with men exhibiting a slightly increased alanine transaminase level (49 IU/L) as only biochemical alteration. In the follow-up, the patients showed undetectable ratHEV RNA and seroconversion to specific ratHEV IgG antibodies. Our study shows that ratHEV is geographical broadly distributed in Spain, representing a potential zoonotic threat.
Áreas temáticas: Ciências biológicas ii Ciências biológicas iii Drug discovery Epidemiology Immunology Infectious diseases Interdisciplinar Medicina ii Medicina veterinaria Medicine (miscellaneous) Microbiology Parasitology Saúde coletiva Virology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: joaquim.peraire@urv.cat
Identificador del autor: 0000-0001-7808-5479
Fecha de alta del registro: 2024-02-18
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2295389
Referencia al articulo segun fuente origial: Emerging Microbes & Infections. 13 (1):
Referencia de l'ítem segons les normes APA: Casares-Jimenez, M; Rivero-Juarez, A; Lopez-Lopez, P; Montes, ML; Navarro-Soler, R; Peraire, J; Espinosa, N; Alemán-Valls, MR; Garcia-Garcia, T; Cabal (2024). Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV. Emerging Microbes & Infections, 13(1), -. DOI: 10.1080/22221751.2023.2295389
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1080/22221751.2023.2295389
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV