Articles producció científica> Medicina i Cirurgia

Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV

  • Datos identificativos

    Identificador: imarina:9334323
    Autores:
    Casares-Jimenez, MRivero-Juarez, ALopez-Lopez, PMontes, MLNavarro-Soler, RPeraire, JEspinosa, NAlemán-Valls, MRGarcia-Garcia, TCaballero-Gomez, JCorona-Mata, DPerez-Valero, IUlrich, RGRivero, A
    Resumen:
    Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species Paslahepevirus balayani), and consequently this group may constitute a high-risk population. We aimed to evaluate the prevalence of ratHEV by measuring viral RNA and specific IgG antibodies in a large Spanish cohort of PLWH. Multicentre study conducted in Spain evaluating PLWHIV included in the Spanish AIDS Research Network (CoRIS). Patients were evaluated for ratHEV infection using PCR at baseline and anti-ratHEV IgG by dot blot analysis to evaluate exposure to ratHEV strains. Patients with detectable ratHEV RNA were followed-up to evaluate persistence of viremia and IgG seroconversion. Eight-hundred and forty-two individuals were tested. A total of 9 individuals showed specific IgG antibodies against ratHEV, supposing a prevalence of 1.1 (95% CI; 0.5%−2.1%). Of these, only one was reactive to HEV IgG antibodies by ELISA. One sample was positive for ratHEV RNA (prevalence of infection: 0.1%; 95% CI: 0.08%−0.7%). The case was a man who had sex with men exhibiting a slightly increased alanine transaminase level (49 IU/L) as only biochemical alteration. In the follow-up, the patients showed undetectable ratHEV RNA and seroconversion to specific ratHEV IgG antibodies. Our study shows that ratHEV is geographical broadly distributed in Spain, representing a potential zoonotic threat.
  • Otros:

    Autor según el artículo: Casares-Jimenez, M; Rivero-Juarez, A; Lopez-Lopez, P; Montes, ML; Navarro-Soler, R; Peraire, J; Espinosa, N; Alemán-Valls, MR; Garcia-Garcia, T; Caballero-Gomez, J; Corona-Mata, D; Perez-Valero, I; Ulrich, RG; Rivero, A
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Peraire Forner, José Joaquin
    Palabras clave: acute hepatitis hiv public health rat hepatitis e virus wild zoonoses Acute hepatitis Hepatitis e Hiv Infection Public health Rat hepatitis e virus Zoonoses
    Resumen: Rat hepatitis E virus (ratHEV; species Rocahepevirus ratti) is considered a newly emerging cause of acute hepatitis of zoonotic origin. ratHEV infection of people living with HIV (PLWH) might portend a worse, as with hepatitis E virus (HEV; species Paslahepevirus balayani), and consequently this group may constitute a high-risk population. We aimed to evaluate the prevalence of ratHEV by measuring viral RNA and specific IgG antibodies in a large Spanish cohort of PLWH. Multicentre study conducted in Spain evaluating PLWHIV included in the Spanish AIDS Research Network (CoRIS). Patients were evaluated for ratHEV infection using PCR at baseline and anti-ratHEV IgG by dot blot analysis to evaluate exposure to ratHEV strains. Patients with detectable ratHEV RNA were followed-up to evaluate persistence of viremia and IgG seroconversion. Eight-hundred and forty-two individuals were tested. A total of 9 individuals showed specific IgG antibodies against ratHEV, supposing a prevalence of 1.1 (95% CI; 0.5%−2.1%). Of these, only one was reactive to HEV IgG antibodies by ELISA. One sample was positive for ratHEV RNA (prevalence of infection: 0.1%; 95% CI: 0.08%−0.7%). The case was a man who had sex with men exhibiting a slightly increased alanine transaminase level (49 IU/L) as only biochemical alteration. In the follow-up, the patients showed undetectable ratHEV RNA and seroconversion to specific ratHEV IgG antibodies. Our study shows that ratHEV is geographical broadly distributed in Spain, representing a potential zoonotic threat.
    Áreas temáticas: Ciências biológicas ii Ciências biológicas iii Drug discovery Epidemiology Immunology Infectious diseases Interdisciplinar Medicina ii Medicina veterinaria Medicine (miscellaneous) Microbiology Parasitology Saúde coletiva Virology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: joaquim.peraire@urv.cat
    Identificador del autor: 0000-0001-7808-5479
    Fecha de alta del registro: 2024-02-18
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.tandfonline.com/doi/full/10.1080/22221751.2023.2295389
    Referencia al articulo segun fuente origial: Emerging Microbes & Infections. 13 (1):
    Referencia de l'ítem segons les normes APA: Casares-Jimenez, M; Rivero-Juarez, A; Lopez-Lopez, P; Montes, ML; Navarro-Soler, R; Peraire, J; Espinosa, N; Alemán-Valls, MR; Garcia-Garcia, T; Cabal (2024). Rat hepatitis E virus (Rocahepevirus ratti) in people living with HIV. Emerging Microbes & Infections, 13(1), -. DOI: 10.1080/22221751.2023.2295389
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.1080/22221751.2023.2295389
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2024
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Drug Discovery,Epidemiology,Immunology,Infectious Diseases,Medicine (Miscellaneous),Microbiology,Parasitology,Virology
    acute hepatitis
    hiv
    public health
    rat hepatitis e virus
    wild
    zoonoses
    Acute hepatitis
    Hepatitis e
    Hiv
    Infection
    Public health
    Rat hepatitis e virus
    Zoonoses
    Ciências biológicas ii
    Ciências biológicas iii
    Drug discovery
    Epidemiology
    Immunology
    Infectious diseases
    Interdisciplinar
    Medicina ii
    Medicina veterinaria
    Medicine (miscellaneous)
    Microbiology
    Parasitology
    Saúde coletiva
    Virology
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