Autor según el artículo: Lorca, C; Fernandez-Rhodes, M; Milan, JAS; Mulet, M; Elortza, F; Ramos-Miguel, A; Callado, LF; Meana, JJ; Mur, M; Batalla, I; Vilella, E; Serra, A; Gallart-Palau, X
Departamento: Medicina i Cirurgia
Autor/es de la URV: Vilella Cuadrada, Elisabet
Palabras clave: Systems biology Psychotic spectrum Psychiatry Neuroinflammation Molecular exchange Immunoglobulins Extracellular vesicles Experience Brain antibodies systems biology psychotic spectrum psychiatry pathology neuroinflammation molecular exchange immunoglobulins cortex cell brain antibodies
Resumen: Extracellular vesicles (EVs) are tiny membranous structures that mediate intercellular communication. The role(s) of these vesicles have been widely investigated in the context of neurological diseases; however, their potential implications in the neuropathology subjacent to human psychiatric disorders remain mostly unknown. Here, by using next-generation discovery-driven proteomics, we investigate the potential role(s) of brain EVs (bEVs) in schizophrenia (SZ) by analyzing these vesicles from the three post-mortem anatomical brain regions: the prefrontal cortex (PFC), hippocampus (HC), and caudate (CAU). The results obtained indicate that bEVs from SZ-affected brains contain region-specific proteins that are associated with abnormal GABAergic and glutamatergic transmission. Similarly, these vesicles from the analyzed regions were implicated in synaptic decay, abnormal brain immunity, neuron structural imbalances, and impaired cell homeostasis. Our findings also provide evidence, for the first time, that networks of molecular exchange (involving the PFC, HC, and CAU) are potentially active and mediated by EVs in non-diseased brains. Additionally, these bEV-mediated networks seem to have become partially reversed and largely disrupted in the brains of subjects affected by SZ. Taken as a whole, these results open the door to the uncovering of new biological markers and therapeutic targets, based on the compositions of bEVs, for the benefit of patients affected by SZ and related psychotic disorders.
Áreas temáticas: Pharmacology & pharmacy Medicine, research & experimental Medicine (miscellaneous) General biochemistry,genetics and molecular biology Ciencias sociales Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all) Biochemistry & molecular biology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: elisabet.vilella@urv.cat
Identificador del autor: 0000-0002-1887-5919
Fecha de alta del registro: 2024-02-17
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2227-9059/12/1/129
Referencia al articulo segun fuente origial: Biomedicines. 12 (1):
Referencia de l'ítem segons les normes APA: Lorca, C; Fernandez-Rhodes, M; Milan, JAS; Mulet, M; Elortza, F; Ramos-Miguel, A; Callado, LF; Meana, JJ; Mur, M; Batalla, I; Vilella, E; Serra, A; Ga (2024). Next-Generation Proteomics of Brain Extracellular Vesicles in Schizophrenia Provide New Clues on the Altered Molecular Connectome. Biomedicines, 12(1), -. DOI: 10.3390/biomedicines12010129
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.3390/biomedicines12010129
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications