Articles producció científica> Psicologia

Sociability: Comparing the Effect of Chlorpyrifos with Valproic Acid

  • Datos identificativos

    Identificador: imarina:9364724
    Autores:
    Morales-Navas MPerez-Fernandez CCastaño-Castaño SSánchez-Gil AColomina MTLeinekugel XSánchez-Santed F
    Resumen:
    In recent years, exposures to organophosphate pesticide have been highlighted as a possible cause or aggravating factor of autism spectrum disorder (ASD). The present study examined if Wistar rats prenatally exposed to chlorpyrifos (CPF) at a dose of 1 mg/kg in GD 12.5-15.5 could express similar behaviors to those exposed to valproic acid (VPA, 400 mg/kg) during the same administration window, which is an accepted animal model of autism. The 3-chambered test was employed to evaluate sociability and reaction to social novelty in two experiments, the first in adolescence and the second in adulthood. The results obtained in this study show that animals prenatally treated with CPF or VPA show a similar behavioral phenotype compared to the control group (CNT). In adolescence, the CPF animals showed a negative index in the reaction to social novelty, followed closely by the VPA, while both experimental groups showed a recovery in this aspect during adulthood. This study therefore provides evidence to suggest that prenatal exposure to CPF in rats could have similar effects on certain components of sociability to those seen in autistic models.© 2024. The Author(s).
  • Otros:

    Autor según el artículo: Morales-Navas M; Perez-Fernandez C; Castaño-Castaño S; Sánchez-Gil A; Colomina MT; Leinekugel X; Sánchez-Santed F
    Departamento: Psicologia
    Autor/es de la URV: Colomina Fosch, Maria Teresa
    Palabras clave: Valproic acid Sociability Pesticides Chlorpyrifos Autism
    Resumen: In recent years, exposures to organophosphate pesticide have been highlighted as a possible cause or aggravating factor of autism spectrum disorder (ASD). The present study examined if Wistar rats prenatally exposed to chlorpyrifos (CPF) at a dose of 1 mg/kg in GD 12.5-15.5 could express similar behaviors to those exposed to valproic acid (VPA, 400 mg/kg) during the same administration window, which is an accepted animal model of autism. The 3-chambered test was employed to evaluate sociability and reaction to social novelty in two experiments, the first in adolescence and the second in adulthood. The results obtained in this study show that animals prenatally treated with CPF or VPA show a similar behavioral phenotype compared to the control group (CNT). In adolescence, the CPF animals showed a negative index in the reaction to social novelty, followed closely by the VPA, while both experimental groups showed a recovery in this aspect during adulthood. This study therefore provides evidence to suggest that prenatal exposure to CPF in rats could have similar effects on certain components of sociability to those seen in autistic models.© 2024. The Author(s).
    Áreas temáticas: Saúde coletiva Psychology, developmental Psychology Psicología Medicina ii Medicina i Interdisciplinar General medicine Educació Developmental and educational psychology Ciencias sociales Ciências biológicas i
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: mariateresa.colomina@urv.cat
    Identificador del autor: 0000-0002-5619-4874
    Fecha de alta del registro: 2024-07-27
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s10803-024-06263-z
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Journal Of Autism And Developmental Disorders.
    Referencia de l'ítem segons les normes APA: Morales-Navas M; Perez-Fernandez C; Castaño-Castaño S; Sánchez-Gil A; Colomina MT; Leinekugel X; Sánchez-Santed F (2024). Sociability: Comparing the Effect of Chlorpyrifos with Valproic Acid. Journal Of Autism And Developmental Disorders, (), -. DOI: 10.1007/s10803-024-06263-z
    DOI del artículo: 10.1007/s10803-024-06263-z
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2024
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Developmental and Educational Psychology,Psychology, Developmental
    Valproic acid
    Sociability
    Pesticides
    Chlorpyrifos
    Autism
    Saúde coletiva
    Psychology, developmental
    Psychology
    Psicología
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Educació
    Developmental and educational psychology
    Ciencias sociales
    Ciências biológicas i
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