Autor según el artículo: Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-Salvadó J; Fitó M; Alonso A
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Salas Salvadó, Jorge
Palabras clave: Alcohol consumption Atrial fibrillation Atrial structure and function
Resumen: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function.URL: http://www.controlled-trials.com; Unique identifier: ISRCTN89898870.
Áreas temáticas: Biotecnología Cardiac & cardiovascular systems Cardiology and cardiovascular medicine Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Medicina i Medicina ii Nutrição Saúde coletiva
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jordi.salas@urv.cat
Identificador del autor: 0000-0003-2700-7459
Fecha de alta del registro: 2024-05-04
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Referencia al articulo segun fuente origial: Journal Of The American Heart Association. 13 (7): e031915-e031915
Referencia de l'ítem segons les normes APA: Alam AB; Toledo-Atucha E; Romaguera D; Alonso-Gómez AM; Martínez-Gonzalez MA; Tojal-Sierra L; Mora MN; Mas-Llado C; Li L; Gonzalez-Casanova I; Salas-S (2024). Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 13(7), e031915-e031915. DOI: 10.1161/JAHA.123.031915
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV