Autor según el artículo: Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; Mas-Llado, Caterina; Li, Linzi; Gonzalez-Casanova, Ines; Salas-Salvado, Jordi; Fito, Montserrat; Alonso, Alvaro
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Salas Salvadó, Jorge
Palabras clave: Volume Validity Stroke Speckle-tracking echocardiography Heart Fibrillation Countries Atrial structure and function Atrial fibrillation Alcohol consumption
Resumen: Background Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention.Methods and Results We studied 503 participants from the PREDIMED-Plus (Prevencion con Dieta Mediterranea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome. Participants underwent transthoracic echocardiography at baseline, year 3, and year 5 of the study. Outcomes of interest included volume index and reservoir, conduit, and contractile strains of the left atrium. Alcohol consumption was calculated through food frequency questionnaires and presented as drinks consumed per day. Multiple linear regression and mixed models estimated the association of alcohol consumption with left atrial measurements at baseline and through follow-up. Cross-sectionally, higher alcohol consumption (per 1 drink/day increases) was associated with larger left atrial volume (0.65 mL/m2 [95% CI, 0.18-1.11]) and lower left atrial reservoir and contractile strain (-0.44% [95% CI, -0.87 to -0.01]; and -0.44% [95% CI, -0.75 to -0.14]). Baseline alcohol consumption was not associated with changes in left atrial measurements, but increases in alcohol consumption (per 1 drink/day increase) during follow-up were associated with left atrial enlargement (0.71 mL/m2 [95% CI, 0.17-1.26]).Conclusions In a population at high cardiovascular risk, increased alcohol consumption was associated with left atrial enlargement and worsening atrial function.Registration URL: http://www.controlled-trials.com; Unique identifier: ISRCTN89898870.
Áreas temáticas: Saúde coletiva Nutrição Medicina ii Medicina i Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jordi.salas@urv.cat
Identificador del autor: 0000-0003-2700-7459
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.ahajournals.org/doi/10.1161/JAHA.123.031915
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of The American Heart Association. 13 (7): e031915-
Referencia de l'ítem segons les normes APA: Alam, Aniqa B; Toledo-Atucha, Estefania; Romaguera, Dora; Alonso-Gomez, Angel M; Martinez-Gonzalez, Miguel A; Tojal-Sierra, Lucas; Mora, Marta Noris; (2024). Associations of Alcohol Consumption With Left Atrial Morphology and Function in a Population at High Cardiovascular Risk. Journal Of The American Heart Association, 13(7), e031915-. DOI: 10.1161/JAHA.123.031915
DOI del artículo: 10.1161/JAHA.123.031915
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV