Autor según el artículo: Garcia-Gavilan, Jesis F; Atzeni, Alessandro; Babio, Nancy; Liang, Liming; Belzer, Clara; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Josep; Moreno-Indias, Isabel; Torres-Collado, Laura; Coltell, Oscar; Toledo, Estefania; Clish, Clary; Hernando, Javier; Yun, Huan; Hernandez-Cacho, Adrian; Jeanfavre, Sarah; Dennis, Courtney; Gomez-Perez, Ana M; Martinez, Maria Angeles; Ruiz-Canela, Miguel; Tinahones, Francisco J; Hu, Frank B; Salas-Salvado, Jordi
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / HERNÁNDEZ CACHO, ADRIÁN / Martínez Rodríguez, María Ángeles / MARTÍNEZ VERA, MARÍA ASUNCIÓN / Salas Salvadó, Jorge
Palabras clave: Sphingolipids Obesity Metabolic syndrome Mediterranean diet Lifestyle intervention Insulin-resistance Glucos Fecal microbiota Fecal metabolome Fecal metabolom Cholesterol Cardiovascular disease risk factor Cardiocascular risk factor Bile-acid Adherence
Resumen: Background: The health bene fi ts of the Mediterranean diet (MedDiet) have been linked to the presence of bene fi cial gut microbes and related metabolites. However, its impact on the fecal metabolome remains poorly understood. Objectives: Our goal was to investigate the weight-loss effects of a 1-y lifestyle intervention based on an energy-reduced MedDiet coupled with physical activity (intervention group), compared with an ad libitum MedDiet (control group), on fecal metabolites, fecal microbiota, and their potential association with cardiovascular disease risk factors. Methods: A total of 400 participants (200 from each study group), aged 55 - 75 y, and at high cardiovascular disease risk, were included. Dietary and lifestyle information, anthropometric measurements, blood biochemical parameters, and stool samples were collected at baseline and after 1 y of followup. Liquid chromatography-tandem mass spectrometry was used to pro fi le endogenous fecal metabolites, and 16S amplicon sequencing was employed to pro fi le the fecal microbiota. Results: Compared with the control group, the intervention group exhibited greater weight loss and improvement in various cardiovascular disease risk factors. We identi fi ed intervention effects on 4 stool metabolites and subnetworks primarily composed of bile acids, ceramides, and sphingosines, fatty acids, carnitines, nucleotides, and metabolites of purine and the Krebs cycle. Some of these were associated with changes in several cardiovascular disease risk factors. In addition, we observed a reduction in the abundance of the genera Eubacterium hallii group and Dorea , and an increase in alpha diversity in the intervention group after 1 y of follow-up. Changes in the intervention -related microbiota pro fi les were also associated with alterations in different fecal metabolite subnetworks and some cardiovascular disease risk factors. Conclusions: An intervention based on an energy -reduced MedDiet and physical activity promotion, compared with an ad libitum MedDiet, was associated with improvements in cardiometabolic risk factors, potentially through modulation of the fecal microbiota and metabolome. This trial was registered at https://www.isrctn.com/ as ISRCTN89898870 (https://doi.org/10.1186/ISRCTN89898870).
Áreas temáticas: Serviço social Saúde coletiva Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina iii Medicina ii Medicina i General medicine Enfermagem Educação física Ciências biológicas ii Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jesusfrancisco.garcia@urv.cat adrian.hernandez@urv.cat alessandro.atzeni@urv.cat mangeles.martinez@urv.cat jesusfrancisco.garcia@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0002-1804-8606 0000-0001-8595-3772 0000-0002-1804-8606 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: American Journal Of Clinical Nutrition. 119 (5): 1143-1154
Referencia de l'ítem segons les normes APA: Garcia-Gavilan, Jesis F; Atzeni, Alessandro; Babio, Nancy; Liang, Liming; Belzer, Clara; Vioque, Jesus; Corella, Dolores; Fito, Montserrat; Vidal, Jos (2024). Effect of 1-year lifestyle intervention with energy-reduced Mediterranean diet and physical activity promotion on the gut metabolome and microbiota: a randomized clinical trial. American Journal Of Clinical Nutrition, 119(5), 1143-1154. DOI: 10.1016/j.ajcnut.2024.02.021
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV