Autor según el artículo: Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi; Yang, Hong; Mulero, Francisca; Puiggros, Francesc; Mardinoglu, Adil; Arola, Lluis; Caimari, Antoni
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Arola Ferrer, Luis Maria / Baudin Luque, Julio Carlos
Palabras clave: Body-composition Carnosine Cell function Complementary and alternative therapie Complementary and alternative therapies Cysteine Elevated plus-maze Expression Food-intake Histidine Immunometabolic health Inflammation Insulin-resistance Menopause Nf-kappa-b Nutraceuticals Obesity Oxidative stress Serine Supplementatio
Resumen: Many women have sought alternative therapies to address menopause. Recently, a multi-ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine has been shown to be effective at ameliorating hepatic steatosis (HS) in ovariectomized (OVX) rats, a postmenopausal oestrogen deficiency model. Considering that HS frequently accompanies obesity, which often occurs during menopause, we aimed to investigate the effects of this MIS for 8 weeks in OVX rats. Twenty OVX rats were orally supplemented with either MIS (OVX-MIS) or vehicle (OVX). Ten OVX rats received vehicle orally along with subcutaneous injections of 17 beta-oestradiol (OVX-E2), whereas 10 rats underwent a sham operation and received oral and injected vehicles (control group). MIS consumption partly counteracted the fat mass accretion observed in OVX animals, leading to decreased total fat mass, adiposity index and retroperitoneal white adipose tissue (RWAT) adipocyte hypertrophy. OVX-MIS rats also displayed increased lean mass and lean/fat ratio, suggesting a healthier body composition, similar to the results reported for OVX-E2 animals. MIS consumption decreased the circulating levels of the proinflammatory marker CRP, the total cholesterol-to-HDL-cholesterol ratio and the leptin-to-adiponectin ratio, a biomarker of diabetes risk and metabolic syndrome. RWAT transcriptomics indicated that MIS favourably regulated genes involved in adipocyte structure and morphology, cell fate determination and differentiation, glucose/insulin homeostasis, inflammation, response to stress and oxidative phosphorylation, which may be mechanisms underlying the beneficial effects described for OVX-MIS rats. Our results pave the way for using this MIS formulation to improve the body composition and immunometabolic health of menopausal women.
Áreas temáticas: Astronomia / física Biodiversidade Biotecnología Ciência da computação Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Educação física Enfermagem Engenharias ii Engenharias iii Farmacia Interdisciplinar Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Medicine, research & experimental Odontología Pharmacology Pharmacology & pharmacy Química Saúde coletiva
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: juliocarlos.baudin@estudiants.urv.cat lluis.arola@urv.cat
Identificador del autor: 0000-0003-2767-1974 0000-0002-1016-4688
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Referencia al articulo segun fuente origial: Biomedicine & Pharmacotherapy. 179 117326-
Referencia de l'ítem segons les normes APA: Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi; Yang, Hong; Mulero, Francisca; Puiggros, Francesc; Mardinoglu, Adil; Arola, Lluis; Ca (2024). A cocktail of histidine, carnosine, cysteine and serine reduces adiposity and improves metabolic health and adipose tissue immunometabolic function in ovariectomized rats. Biomedicine & Pharmacotherapy, 179(), 117326-. DOI: 10.1016/j.biopha.2024.117326
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV