Repositori URV

Autor según el artículo: Fontanals, Nuria; Marce, Rosa Maria; Montes, Rosa; Rodil, Rosario; Gonzalez-Marino, Iria; Valcarcel, Yolanda; Rodriguez-Mozaz, Sara; Borrull, Francesc; Quintana, Jose Benito; Pocurull, Eva

Departamento: Química Analítica i Química Orgànica

Autor/es de la URV: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria / Pocurull Aixala, Eva

Palabras clave: Wastewater-based epidemiology Pharmaceuticals Influent wastewater Dispensed pharmaceutical data Consumption Consumptio

Resumen: Wastewater-based epidemiology (WBE) is a well-established approach that can provide objective and real-time data on the consumption of substances such as pharmaceuticals. However, most of the studies reported so far compares consumption data obtained using WBE with those derived from prescription data from public health systems, which is often incomplete and might represent a source of uncertainty. This study aims to compare the measured pharmaceutical consumption back calculated with the WBE approach with consumption derived from dispensed pharmaceuticals in two regions of Spain, managed by two different Health Systems. To do so, a group of 17 pharmaceuticals, including the most representative ones of every therapeutic family, were monitored in influent wastewater (IWW) samples collected over a week campaign in spring 2022 at four different wastewater treatment plants (WWTPs) in Spain: two WWTPs in Madrid city (center of Spain) and two WWTPs in Catalonia (Northeast of Spain). Population-normalized daily loads (PNDL) revealed that the patterns of pharmaceutical occurrence in the different WWTPs are very similar, being acetaminophen, 4-acetamidoantipyrine and valsartan the pharmaceuticals with the highest PNDL values: 17162 +/- 1457 mg day(- 1) 1000 inh(-1 )for acetaminophen, 2365 +/- 696 and 2429 +/- 263 mg day(- 1) 1000 inh(-1) for 4-acetamidoantipyrine, 2006 +/- 541 and 2041 +/- 352 mg day(- 1 )1000 inh(-1) for valsartan. Pharmaceutical PNLDs were then transformed into measured pharmaceutical consumption (MC) and compared with dispensed consumption (DC) data obtained from the pharmacies in the catchment area where the WWTPs are located. A ratio MC/DC within 0.8 to 1.2 was obtained for 11 out of the 17 studied pharmaceuticals. Highlighting a match in all the cardiovascular system pharmaceuticals, with the exception of losartan (1.29-1.39 ratio) and valsartan (1.35-1.43) in all WWTPs. In summary, the degree of correlation between MC/DC is higher than those previously reported comparing with the prescribed pharmaceutical consumption.

Áreas temáticas: Zootecnia / recursos pesqueiros Waste management and disposal Saúde coletiva Química Pollution Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Historia Geografía Geociências Farmacia Environmental sciences Environmental engineering Environmental chemistry Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: francesc.borrull@urv.cat rosamaria.marce@urv.cat eva.pocurull@urv.cat nuria.fontanals@urv.cat

Identificador del autor: 0000-0003-2718-9336 0000-0002-5667-2899 0000-0001-5123-995X 0000-0002-7534-1964

Fecha de alta del registro: 2024-10-05

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0048969724062648?via%3Dihub

Referencia al articulo segun fuente origial: Science Of The Total Environment. 953 176108-

Referencia de l'ítem segons les normes APA: Fontanals, Nuria; Marce, Rosa Maria; Montes, Rosa; Rodil, Rosario; Gonzalez-Marino, Iria; Valcarcel, Yolanda; Rodriguez-Mozaz, Sara; Borrull, Francesc (2024). Wastewater-based epidemiology to assess pharmaceutical consumption. Spanish perspective. Science Of The Total Environment, 953(), 176108-. DOI: 10.1016/j.scitotenv.2024.176108

URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/

DOI del artículo: 10.1016/j.scitotenv.2024.176108

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2024

Tipo de publicación: Journal Publications