Autor según el artículo: Baudin, Julio; Hernandez-Baixauli, Julia; Quesada-Vazquez, Sergio; Mulero, Francisca; Puiggros, Francesc; Arola, Lluis; Caimari, Antoni
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Arola Fernández, Lluís / Arola Ferrer, Luis Maria / Baudin Luque, Julio Carlos
Palabras clave: Adiponecti Adiposity Animals Bone loss Cardiovascular-disease Curcumin Dietary supplements Energy-expenditure Female Hesperidin Humans Inflammation Insulin-resistance Leptin Menopause Model Obesity Ovariectomy Phytosterols Rats Rats, sprague-dawley Rats, wistar
Resumen: In recent years many women have looked for alternative therapies to address menopause. Hesperidin, phytosterols and curcumin are bioactive compounds that can ameliorate some cardiovascular risk factors associated with menopause, although there are no data concerning the effects of their combined supplementation. We used ovariectomized (OVX) rats, a postmenopausal model with oestrogen deficiency, to evaluate whether supplementation with a multi-ingredient (MI) including hesperidin, phytosterols and curcumin for 57 days would display beneficial effects against fat mass accretion and metabolic disturbances associated with menopause. Twenty OVX rats were orally supplemented with either MI (OVX-MI) or vehicle (OVX). Furthermore, 10 OVX rats orally received the vehicle along with subcutaneous injections of 17 beta-oestradiol biweekly (OVX-E2), whereas 10 rats were sham operated and received oral and injected vehicles (control group; SH). MI supplementation partly counteracted the fat mass accretion observed in OVX animals, which was evidenced by decreased total fat mass, adiposity index, the weight of retroperitoneal, inguinal and mesenteric white adipose tissue (MWAT) depots and MWAT adipocyte hypertrophy. These effects were accompanied by a significant decrease in the circulating levels of leptin and the mRNA levels of the fatty acid uptake-related genes Lpl and Cd36 in MWAT. These results were very similar to those observed in OVX-E2 animals. OVX-MI rats also displayed a higher lean body mass, lean/fat mass ratio, adiponectin-to-leptin ratio and insulin sensitivity than their OVX counterparts. Our findings can pave the way for using this MI formulation as an alternative therapy to manage obesity and to improve the cardiometabolic health of menopausal women. In recent years many women have looked for alternative therapies to address menopause.
Áreas temáticas: Biochemistry & molecular biology Biotecnología Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Educação física Farmacia Food science Food science & technology Interdisciplinar Materiais Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Nutrição Odontología Química Saúde coletiva Zootecnia / recursos pesqueiros
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: lluis.arola@urv.cat lluis.arola@estudiants.urv.cat lluis.arola@estudiants.urv.cat juliocarlos.baudin@estudiants.urv.cat
Identificador del autor: 0000-0003-2767-1974 0000-0002-1016-4688
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://pubs.rsc.org/en/content/articlelanding/2024/fo/d3fo05122f
Referencia al articulo segun fuente origial: Food & Function. 15 (9): 4905-4924
Referencia de l'ítem segons les normes APA: Baudin, Julio; Hernandez-Baixauli, Julia; Quesada-Vazquez, Sergio; Mulero, Francisca; Puiggros, Francesc; Arola, Lluis; Caimari, Antoni (2024). Combined supplementation with hesperidin, phytosterols and curcumin decreases adiposity and improves metabolic health in ovariectomized rats. Food & Function, 15(9), 4905-4924. DOI: 10.1039/d3fo05122f
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.1039/d3fo05122f
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV