Autor según el artículo: Martinez, Maria Angeles; Salas-Huetos, Albert; de la Puente, Maria Fernandez; Valle-Hita, Cristina; Marques, Montse; Del Egido-Gonzalez, Claudia; Davila-Cordova, Estefania; Mestres, Cristina; Petersen, Maria Skaalum; Babio, Nancy; Salas-Salvado, Jordi
Departamento: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Medicina i Cirurgia
Autor/es de la URV: Babio Sánchez, Nancy Elvira / Davila Córdova, Jennifer Estefania / Fernández de la Puente Cervera, María / Marquès Bueno, Montserrat / Martínez Rodríguez, María Ángeles / MARTÍNEZ VERA, MARÍA ASUNCIÓN / Mestres Solà, Cristina / Salas Huetos, Albert / Salas Salvadó, Jorge / Valle Hita, Cristina
Palabras clave: Young adult Variabilit Sulfones Spain Semen quality Semen analysis Reproductive health Phenols Middle aged Men Male Infertility Humans Exposure Environmental pollutants Environmental exposure Endocrine-disrupting chemicals Endocrine disruptors Cross-sectional studies Chemical analogues Chemical analogue Bpa Bisphenols Bisphenol s Bisphenol f Bisphenol a Benzhydryl compounds Adult
Resumen: Infertility is recognized as a multifaceted condition affecting approximately 15% of couples globally, influenced by various factors including genetic predisposition and environmental exposures. Among these environmental factors, bisphenol A (BPA) emerges as a prominent Endocrine-disrupting chemical (EDCs) widely distributed, leading to chronic human exposure in daily life. As regulations on BPA became more stringent, alternative substances such as bisphenol S (BPS) and bisphenol F (BPF) have emerged. Animal studies have demonstrated a dose-dependent decline in fertility and embryotoxicity following chronic exposure to BPA. However, literature data on human studies are limited and heterogeneous. Additionally, even less is known about the relationship between exposure to the BPA analogues (BPS and BPF) and sperm quality. Therefore, the present study aimed to examine the association between urinary concentrations of BPA, BPF, and BPS and semen quality parameters among 195 adult Spanish men from the Led-Fertyl study cohort using multiple linear regression models adjusted by potential confounding variables. Our results revealed an inverse association between log-transformed creatinine-adjusted concentration (ng/mg) of BPA and BPF levels and the percentage of sperm vitality (/i: 3.56 %; 95%CI: 6.48 to -0.63 and /i: 4.14 %; 95%CI: 6.97 to -1.31; respectively). Furthermore, participants in the highest quartile of BPA and BPF urinary concentration exhibited lower sperm vitality compared to those in the lowest quartile (/i: 6.90 %; 95%CI: 11.60 to -2.15 and /i: 9.68 %; 95%CI: 14.43 to -4.94; respectively). These results supply epidemiological evidence establishing a relationship between bisphenols urine exposure and sperm quality, suggesting that a re-evaluation of the overall safety of BPA alternatives is warranted.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: maria.fernandezdelapuente@urv.cat cristina.mestres@urv.cat albert.salas@urv.cat montserrat.marques@urv.cat mangeles.martinez@urv.cat jenniferestefania.davila@estudiants.urv.cat maria.fernandezdelapuente@urv.cat cristina.valle@alumni.urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Identificador del autor: 0000-0001-5914-6862 0000-0001-6302-8578 0000-0001-8595-3772 https://orcid.org/0000-0003-1153-9397 0000-0003-2700-7459 0000-0003-3527-5277
Fecha de alta del registro: 2025-03-15
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Referencia al articulo segun fuente origial: Environmental Research. 263 (Pt 2): 120086-
Referencia de l'ítem segons les normes APA: Martinez, Maria Angeles; Salas-Huetos, Albert; de la Puente, Maria Fernandez; Valle-Hita, Cristina; Marques, Montse; Del Egido-Gonzalez, Claudia; Davi (2024). Exploring the association between urinary bisphenol A, S, and F levels and semen quality parameters: Findings from Led-Fertyl cross-sectional study. Environmental Research, 263(Pt 2), 120086-. DOI: 10.1016/j.envres.2024.120086
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV