Articles producció científica> Bioquímica i Biotecnologia

Faecal microbiota composition and impulsivity in a cohort of older adults with metabolic syndrome.

  • Datos identificativos

    Identificador: imarina:9391513
    Handle: https://hdl.handle.net/20.500.11797/imarina9391513
    Autores:
    Konstanti PGómez-Martínez CMuralidharan JVioque JCorella DFitó MVidal JTinahones FJTorres-Collado LColtell OCastañer OMoreno-Indias IAtzeni ARuiz-Canela MSalas-Salvadó JBelzer C
    Resumen:
    Impulsivity is an important determinant of human behaviour, affecting self-control, reasonable thinking and food choices. Recent evidence suggests a role for gut microbiota in human behaviour, but the relationship between gut microbiota and impulsive behaviours remains largely unexplored. To address this knowledge gap, the present study aims to explore the associations between faecal microbiota composition with trait and behavioural impulsivity, in a subcohort of the PREDIMED-Plus trial, including older adults presenting overweight/obesity. Fecal samples (n = 231) were profiled for their microbiota composition using 16 S rRNA amplicon sequencing and impulsivity was determined through four different assessments. Adherence to different dietary patterns was estimated through questionnaires. Beta diversity analyses showed a significant association with the Conner's Performance Test (CPT) in multivariate-adjusted models, and, in total, 13 bacterial genera associated with CPT. Erysipelotrichaceae UCG 003 showed the highest association with CPT and known butyrate producers such as Butyricicoccus spp., Roseburia spp., and Eubacterium hallii were among the identified bacteria. The bacteria Lachnospiraceae UCG 001, Anaerostipes and Blautia were associated with CPT and also the adherence to healthy and unhealthy plant-based diets. In addition, functional analysis showed a significant negative association between the CPT and the glucuronate and galacturonate metabolic pathways. From the other impulsivity assessments, two more associations were identified, for the genus Phascolarctobacterium with the Stroop test, and the genus Lachnospiraceae GAG 54 with the positive urgency subscore of UPPS-P Impulsive Behaviour Scale. Overall, our findings suggest potential links between the faeca

  • Otros:

    Autor según el artículo: Konstanti P; Gómez-Martínez C; Muralidharan J; Vioque J; Corella D; Fitó M; Vidal J; Tinahones FJ; Torres-Collado L; Coltell O; Castañer O; Moreno-Indias I; Atzeni A; Ruiz-Canela M; Salas-Salvadó J; Belzer C
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Atzeni, Alessandro / Gómez Martínez, Carlos / Muralidharan, Jananee / Salas Salvadó, Jorge
    Palabras clave: Rna, ribosomal, 16s Middle aged Metabolic syndrome Male Impulsive behavior Humans Gastrointestinal microbiome Female Feces Cohort studies Bacteria Aged
    Resumen: Impulsivity is an important determinant of human behaviour, affecting self-control, reasonable thinking and food choices. Recent evidence suggests a role for gut microbiota in human behaviour, but the relationship between gut microbiota and impulsive behaviours remains largely unexplored. To address this knowledge gap, the present study aims to explore the associations between faecal microbiota composition with trait and behavioural impulsivity, in a subcohort of the PREDIMED-Plus trial, including older adults presenting overweight/obesity. Fecal samples (n = 231) were profiled for their microbiota composition using 16 S rRNA amplicon sequencing and impulsivity was determined through four different assessments. Adherence to different dietary patterns was estimated through questionnaires. Beta diversity analyses showed a significant association with the Conner's Performance Test (CPT) in multivariate-adjusted models, and, in total, 13 bacterial genera associated with CPT. Erysipelotrichaceae UCG 003 showed the highest association with CPT and known butyrate producers such as Butyricicoccus spp., Roseburia spp., and Eubacterium hallii were among the identified bacteria. The bacteria Lachnospiraceae UCG 001, Anaerostipes and Blautia were associated with CPT and also the adherence to healthy and unhealthy plant-based diets. In addition, functional analysis showed a significant negative association between the CPT and the glucuronate and galacturonate metabolic pathways. From the other impulsivity assessments, two more associations were identified, for the genus Phascolarctobacterium with the Stroop test, and the genus Lachnospiraceae GAG 54 with the positive urgency subscore of UPPS-P Impulsive Behaviour Scale. Overall, our findings suggest potential links between the faecal microbiota composition and function with behavioural impulsive inattention as determined by the CPT.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: carlos.gomez@urv.cat alessandro.atzeni@urv.cat carlos.gomez@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat
    Identificador del autor: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0003-2700-7459
    Fecha de alta del registro: 2024-11-23
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Referencia al articulo segun fuente origial: Scientific Reports. 14 (1): 28075-
    Referencia de l'ítem segons les normes APA: Konstanti P; Gómez-Martínez C; Muralidharan J; Vioque J; Corella D; Fitó M; Vidal J; Tinahones FJ; Torres-Collado L; Coltell O; Castañer O; Moreno-Ind (2024). Faecal microbiota composition and impulsivity in a cohort of older adults with metabolic syndrome.. Scientific Reports, 14(1), 28075-. DOI: 10.1038/s41598-024-78527-8
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2024
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Multidisciplinary,Multidisciplinary Sciences
    Rna, ribosomal, 16s
    Middle aged
    Metabolic syndrome
    Male
    Impulsive behavior
    Humans
    Gastrointestinal microbiome
    Female
    Feces
    Cohort studies
    Bacteria
    Aged
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física

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