Revistes Publicacions URV: SORT - Statistics and Operations Research Transactions> 2016

Two alternative estimation procedures for the negative binomial cure rate model with a latent activation scheme

  • Dades identificatives

    Identificador: RP:2438
    Handle: https://hdl.handle.net/20.500.11797/RP2438
    Autors:
    Bolfarine, HelenoGallardo, Diego I.
    Resum:
    In this paper two alternative estimation procedures based on the EM algorithm are proposed forthe flexible negative binomial cure rate model with a latent activation scheme. The Weibull modelas well as the log-normal and gamma distributions are also considered for the time-to-event datafor the non-destroyed cells. Simulation studies show the satisfactory performance of the proposedmethodology. The impact of misspecifying the survival function on both components of the model(cured and susceptible) is also evaluated. The use of the new methodology is illustrated with areal data set related to a clinical trial on Phase III cutaneous melanoma patients.

  • Altres:

    Autor/s de la URV: Bolfarine, Heleno Gallardo, Diego I.
    Paraules clau: Competing risks, EM algorithm, latent activation scheme
    Resum: In this paper two alternative estimation procedures based on the EM algorithm are proposed forthe flexible negative binomial cure rate model with a latent activation scheme. The Weibull modelas well as the log-normal and gamma distributions are also considered for the time-to-event datafor the non-destroyed cells. Simulation studies show the satisfactory performance of the proposedmethodology. The impact of misspecifying the survival function on both components of the model(cured and susceptible) is also evaluated. The use of the new methodology is illustrated with areal data set related to a clinical trial on Phase III cutaneous melanoma patients.
    Any de publicació de la revista: 2016
    Tipus de publicació: info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article

  • Paraules clau:

    Competing risks, EM algorithm, latent activation scheme

  • Documents:

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