Revistes Publicacions URV: SORT - Statistics and Operations Research Transactions> 2014

Assessing the impact of early detection biases on breast cancer survival of Catalan women

  • Identification data

    Identifier: RP:2412
    Handle: https://hdl.handle.net/20.500.11797/RP2412
    Authors:
    Rué, MontserratMarcos-Gragera, RafaelGalceran, JaumeMacià, FrancescForné, CarlesRoso-Llorach, Albert
    Abstract:
    Survival estimates for women with screen-detected breast cancer are affected by biases specific to early detection. Lead-time bias occurs due to the advance of diagnosis, and length-sampling bias because tumors detected on screening exams are more likely to have slower growth than tumors symptomatically detected. Methods proposed in the literature and simulation were used to assess the impact of these biases. If lead-time and length-sampling biases were not taken into account, the median survival time of screen-detected breast cancer cases may be overestimated by 5 years and the 5-year cumulative survival probability by between 2.5 to 5 percent units.

  • Others:

    URV's Author/s: Rué, Montserrat Marcos-Gragera, Rafael Galceran, Jaume Macià, Francesc Forné, Carles Roso-Llorach, Albert
    Keywords: Breast cancer, early detection, screening, lead time bias, length bias, survival
    Abstract: Survival estimates for women with screen-detected breast cancer are affected by biases specific to early detection. Lead-time bias occurs due to the advance of diagnosis, and length-sampling bias because tumors detected on screening exams are more likely to have slower growth than tumors symptomatically detected. Methods proposed in the literature and simulation were used to assess the impact of these biases. If lead-time and length-sampling biases were not taken into account, the median survival time of screen-detected breast cancer cases may be overestimated by 5 years and the 5-year cumulative survival probability by between 2.5 to 5 percent units.
    Journal publication year: 2014
    Publication Type: info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article

  • Keywords:

    Breast cancer, early detection, screening, lead time bias, length bias, survival

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