The activation of diboron reagents and their application in catalytic boron additions to alkenes

Identificador:  TDX:1044

Handle:  https://hdl.handle.net/20.500.11797/TDX1044

Autors:  Bonet Laplana, Amadeu

Resum:
Organoborane compounds are highly used in a huge number of fields, from medicine, in the boron neutral capture therapy or other molecules with biological activity to the use of functional molecules such us polymers. In our case, we focused our atention in the use of organoborane compounds as a intermediates for the synthesis of high value products. The main topic of this thesis is develop new synthetic methodologies for the efficient obtaition of organoborane compounds. We focus in the synthesis of -boryl carbonyl compounds as a synthons for the synthesis of difuncional molecules. We studied the boron addition to unsaturated molecules in to main strategies: the boron addition using transition metal catalyst or without metal. Always with special attention for the chiral approach of the reaction.