Exploring new gold-catalyzed cyclization reactions of 1,5-enynes and development of an intermolecular phenol synthesis

Identificador:  TDX:1173

Handle: https://hdl.handle.net/20.500.11797/TDX1173

Autors:  Huguet i Subiela, Núria

Resum:
Gold salts and complexes are the most active catalysts for the activation of alkynes, allenes and alkenes. Part of this Doctoral Thesis is focused on the study of the carbenic or cationic character of the reaction intermediates presents in the cycloisomerizations of 1,5-enynes catalyzed by goldcomplexes. Different methodologies have been developed to synthesize different tryciclic products from oxo-1,5-enynes or 1,5-benzylenynes. Moreover, these methodologies were applied successfully as the key step in the synthesis of natural products. Finally, our interest was focused on the development of intermolecular gold-catalyzed reactions. Therefore, we have developed a general synthesis of trisubstituted phenols from alkynes and furans.