Papel de factores endocrinos como melatonina y prolactina, y de adipoquinas como leptina en la modulación de la inflamación asociada a procesos neurodegenerativos

Identificador:  TDX:2090

Handle: https://hdl.handle.net/20.500.11797/TDX2090

Autors:  Patraca Fierro, José Iván

Resum:
Glia is the group most abundant cells in the brain nervous system, for a long time it was considered only as an element of support neuronal unimportant. Hence the need to investigate the behavior and characterization of it in response to the loss of memory and both intracellular signal activation, survival and cognitive impairment. In mixed culture of mouse cortex C57Bl / 6J, 9 day treatment growth after planting, one hour activation with leptin and prolactin after incubation of cytokines (IFNy, IL-1β and TNF) for 48 hours. Of particular note the connection of signaling molecules activated by oxidative stress as they are p38 and iNOS MAKP focused. Neuroprotective effect of adipokines as: Melatonin, prolactin and leptin and its effects on the inhibition of nitric oxide production and iNOS expression, through p38-MAKP after treatments cytokine inhibiting cell damage astrocyte supporting the anti-inflammatory and antioxidant potential of these compounds, and their potential application in the treatment of specific neurological disorders, suggesting pathways involved in the early stages of Alzheimer's disease.