Regulación genético-ambiental del estado nutricional de la vitamina b2 e influencia sobre el ciclo de la metionina en una población adulta y en gestantes

Identifier:  TDX:1315

Handle: https://hdl.handle.net/20.500.11797/TDX1315

Authors:  García-Minguillán del Campo, Carlos Jesús

Abstract:
MTHFR and MTRR, riboflavin dependent enzymes, participate in homocysteine metabolism. Their substrates,folate and cobalamin, respectively, are inversely associated with fasting plasma homocysteine (tHcy). Riboflavin status may also affect tHcy. We investigated whether riboflavin, folate and cobalamin status affect the association between the MTHFR 677 C>T, MTRR 66 A>G orMTRR 524 C>T polymorphisms and tHcy in an adult population and in pregnant women. Riboflavin status was inversely associated with tHcy in the presence of the MTHFR 677 TT genotype, independently of folate status. High riboflavin status was positively associated with tHcy in carriers of the MTRR 66 A>Gmutant allele but inversely associated with tHcy in MTRR 524 C>T mutant allele carriers when cobalamin status was low. High riboflavin combined with low cobalamin status was positively associated with tHcy in pregnant carriers of mutant alleles for either of the latter polymorphisms.