Glycolipids: synthesis and multivalent systems

Identifier:  TDX:1431

Handle: https://hdl.handle.net/20.500.11797/TDX1431

Authors:  Cobo Cardenete, Isidro Felipe

Abstract:
Glycolipids such as glycosphingolipids are interesting compounds because they can interact with biofactors by inhibiting or interfering in physiological processes on cells. For instance, the glycolipids which present on cellular membranes can interact with bacteria, virus and toxins. In deed, Cholera toxin starts its infective process once it has recognized glycolipids such as GM1. Although the use of antibiotics is the commonest treatment against this disease, the antibiotic resistance in endemic areas makes the investigation in the synthesis of inhibitors based on carbohydrate derivatives necessary. Due to the synthesis of multivalent glycoconjugated compounds have been competitive in order to prepare inhibitors against these pathogens, in the present work we have studied: the synthesis of new mimetics based on -galactosylceramides; the Suzuki-Miyaura cross coupling in 2-iodoglycals in order to obtain new carbohydrate precursors and the anchoring of -galactosylceramides in scaffolds such as hyperbranched polymers in order to evaluate their inhibition binding against to Cholera toxin