Constitutive modeling of the male pelvic system to improve the accuracy of the location of neoplasms in MRI-TRUS fusion prostate biopsy

Identifier:  TDX:4179

Handle: https://hdl.handle.net/20.500.11797/TDX4179

Authors:  Qasim, Muhammad

Abstract:
Computational modeling of the human pelvis using the finite element (FE) method has become extremely important to understand the mechanics of prostate motion and deformation when transrectal ultrasound (TRUS) guided biopsy is performed. The number of reliable and validated constitutive FE models of the male pelvis region is limited, and the given models did not precisely describe the anatomical behavior of pelvis organs, mainly of the prostate and its neoplasms location. Prostate lesions are visible in Magnetic Resource Imaging (MRI) but it is difficult for radiologists to locate them at the time of performing transrectal ultrasound (TRUS) guided biopsy. Consequently, multiple biopsy samples are required to target one single lesion. The three-dimensional (3-D) anatomy model of the pelvic region (comprised of the rectum, bladder, pelvic muscles, prostate transitional zone (TZ), and peripheral zone (PZ)), based on medical images, is constructed and used for the simulations. We implemented our new methodology that can help to predict the location of neoplasms during a prostate biopsy. Moreover, the new methodology is completely developed on open-source software, which means that its implementation would be affordable to all healthcare providers. Last but not least, we presented our new model for the anisotropic-viscoelastic behavior of the prostate