Tesis doctorals> Departament de Medicina i Cirurgia

Estudi del canal de glicerol aqp7 i de l'adipoquina zag en l'àmbit de l'obesitat, la diabetis tipus 2 i la síndrome metabòlica. Dues proteïnes implicades en la lipòlisi del teixit adipós

  • Identification data

    Identifier: TDX:661
    Authors:
    Ceperuelo Mallafré, Mª Victòria
    Abstract:
    Obesity increases the chances to suffer from other diseases such as type 2 diabetes mellitus (T2DM), hyperlipidemia, hypertension, and others. In order to get into new therapeutic targets to improve these conditions, a best knowledge of the biology of adipose tissue and its components is needed. In addition to storing the most of energy reserves, white adipose tissue is able to have metabolic and endocrine activity. It is necessary to consider that an appropriate lipid metabolism in the adipocyte is also essential to achieve a balance in the homeostasis of glucose metabolism in humans. In this study we have examined the role of two proteins involved in adipose tissue lipolysis, first glycerol channel aquaporin 7 (AQP7) and on the other hand adipokine Zinc-α 2 glycoprotein (ZAG), in the context of obesity, metabolic syndrome and T2DM. Thus, in this thesis, we have reached the following conclusions: 1. The glycerol's channel AQP7 expression, in adipose tissue, is decreased in patients with morbid obesity. 2. The DM2 does not appear to affect the expression of this aquaglyceroporin in adipose tissue. 3. Both aquaglyceroporins, AQP7 (in adipose tissue) and AQP9 (in liver tissue) have a close relationship in morbidly obese patients. 4. The Zinc-α 2 glycoprotein (ZAG) seems to play an important role in the homeostasis of adipose tissue with a strong bond with other adipokines, particularly adiponectin.
  • Others:

    Date: 2010-05-14
    Departament/Institute: Departament de Medicina i Cirurgia Universitat Rovira i Virgili.
    Language: eng
    Identifier: urn:isbn:9788469354292 http://hdl.handle.net/10803/8883
    Source: TDX (Tesis Doctorals en Xarxa)
    Author: Ceperuelo Mallafré, Mª Victòria
    Director: Vendrell Ortega, Juan José Miranda Guardiola, Merce Rodríguez Chacón, Matilde
    Format: application/pdf
    Publisher: Universitat Rovira i Virgili
    Keywords: teixit adipós aquaporina adipoquina obesitat i diabetis
    Title: Estudi del canal de glicerol aqp7 i de l'adipoquina zag en l'àmbit de l'obesitat, la diabetis tipus 2 i la síndrome metabòlica. Dues proteïnes implicades en la lipòlisi del teixit adipós
    Subject: 61 - Medicina 577 - Bioquímica. Biologia molecular. Biofísica
  • Keywords:

    61 - Medicina
    577 - Bioquímica. Biologia molecular. Biofísica
  • Documents:

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