Tesis doctorals> Departament de Psicologia

Efectos neuroconductuales derivados de la exposicion a clorpirifos en un modelo animal de la enfermedad de Alzheimer

  • Identification data

    Identifier: TDX:920
    Authors:
    Salazar, José Gregorio
    Abstract:
    Chlorpyrifos (CPF) is a widely used organophosphate insecticide. Neurotoxic effects derive primarily from the inhibition of cholinesterase. Different studies have shown behavioral and cognitive effects of exposure to CPF. In the present study, we evaluated the neurobehavioral effects resulting from exposure to an acute dose and repeated doses of CPF, in a transgenic mouse model (Tg2576) carrying the Swedish mutation responsible for a familial form of Alzheimer's disease. We evaluated the effects on exploratory activity, learning and spatial memory and motor coordination. Acetylcholinesterase activity, levels of beta-amyloid (1-40, 1-42), proliferation and cell differentiation and expression of BACE1, were determined. The results showed cognitive improvement in Tg exposed to CPF. However, we observed an increase in the levels of A in the treated Tg, which would be a long term worsening of the neurodegenerative process.
  • Others:

    Date: 2011-04-11
    Departament/Institute: Departament de Psicologia Universitat Rovira i Virgili.
    Language: spa
    Identifier: http://hdl.handle.net/10803/32886
    Source: TDX (Tesis Doctorals en Xarxa)
    Author: Salazar, José Gregorio
    Director: Colomina Fosch, Mª Teresa Sánchez Santed, Luis Fernando
    Format: application/pdf 238 p.
    Publisher: Universitat Rovira i Virgili
    Keywords: Tg2576 neuroconductual Alzheimer Clorpirifos
    Title: Efectos neuroconductuales derivados de la exposicion a clorpirifos en un modelo animal de la enfermedad de Alzheimer
    Subject: 616.89 - Psiquiatria. Psicopatologia 616.8 - Neurologia. Neuropatologia. Sistema nerviós 615 - Farmacologia. Terapèutica. Toxicologia. Radiologia 577 - Bioquímica. Biologia molecular. Biofísica
  • Keywords:

    616.89 - Psiquiatria. Psicopatologia
    616.8 - Neurologia. Neuropatologia. Sistema nerviós
    615 - Farmacologia. Terapèutica. Toxicologia. Radiologia
    577 - Bioquímica. Biologia molecular. Biofísica
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