Immunogenètica i Immunopatogènia de la infecció pel VIH-1 en la població espanyola. Influència sobre la història natural de la infecció.

Identificador:  TDX:636

Handle: https://hdl.handle.net/20.500.11797/TDX636

Autores:  Peraire Forner, Josep Joaquím

Resumen:
Thesis based on 3 immunogenetics studies whose objective are to determine whether the major allelic variants of the main HIV-1 coreceptors through which HIV-1 enters into host cells (CCR5 and CXCR4) and their natural and respective ligands RANTES and SDF-1 chemokines, modulate the risk of infection and/or the natural history in a cohort of Spanish Caucasian patients. A fourth immunopathogenic study evaluates the posible relationship between mitochondrial damage and apoptosis, both HIV-1 induced, in peripheral blood mononuclear cells (PBMC). The immunogenetic studies do not find any association between chemokines allelic variants and HIV-1 coreceptors in long-term non progressor patients. In the immunopathogenic study an association between mitochondrial damage and apoptosis is found in the PBMCs of patients with active HIV-1 replication.