Synthesis and characterization of PACAP23 glycopeptides for improved stability and transport

Identifier:  TFG:3780

Handle: https://hdl.handle.net/20.500.11797/TFG3780

Authors:  Varela Guerrero, Daniel

Abstract:
PAPAC38 and PACAP27 are endogenous peptides which have been studied for their properties against neurodegenerative diseases. Recently, it was studied if an easier to make version could also present these properties, and the results showed that PACAP23 was the shortest bioactive compound. Despite its positive effects, peptides present a series of drawbacks and a difficulty in crossing the BBB. Glycosylation has proved effective to help with these problems. Because of that, the success in the synthesis of a glycosylated PACAP23 could open a wide range of possibilities for the design of a drug meant for the treatment of these diseases.