Exosomes: Crosstalk mediators of the breast cancer microenvironment

Identifier:  TFG:4147

Handle: https://hdl.handle.net/20.500.11797/TFG4147

Authors:  Avivar Sáez, Ylènia

Abstract:
Adipocytes are the most abundant cell type in the breast tissue and exosomes are being discussed as participants of the communication between cells, owing to the fact that they transfer cellular components to paracrine cells. This study aims to examine the role of FABP4 in adipocytes-derived exosomes and its role in the crosstalk of the tumour microenvironment. In order to study the role of exosomes in the tumour microenvironment, we isolated adipocyte-derived exosomes after their treatment with different conditions and analysed them by Western Blot. CAAs release more FA to the media, accompanied by FATP, more exosomes than adipocytes and also the cargo of FABP4 and CD36 was increased. These results provide new insights into the role of FABP4 and CD36 within exosomes in the crosstalk of the tumour microenvironment.