In silico mechanistic study of the potential use of NSAIDs to accelerate the healing of patients with pulmonary tuberculosis

Identifier:  TFG:4455

Handle: https://hdl.handle.net/20.500.11797/TFG4455

Authors:  Farré Zapater, Alexandra

Abstract:
Pulmonary tuberculosis (PTB) is one of the 10 leading causes of death worldwide. One of the biggest concerns is resistance to antibiotics, the anti-microbial therapy which is used in the current therapeutic regimen against PTB. Due to the long duration and low effectiveness of the treatment in these patients, inflammation remains throughout the months, increasing severity of the disease. Thus, non-steroidal anti-inflammatory drugs (NSAIDs) are suggested as a potential therapeutic option to improve the prognosis of PTB patients. NSAIDs mechanistic relationship with PTB has been evaluated by in silico studies together with their potential molecular mechanism of action in PTB.