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Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity

  • Identification data

    Identifier: TFG:4464
    Authors:
    Portillo Carrasquer, Marta
  • Others:

    Creation date in repository: 2022-03-01
    Abstract: The aim of this study is to analyse the role of SFRP5 in women with morbid obesity and NAFLD. We found that irculating SFRP5 levels increase after a caloric restriction in subjects with MO regardless of NAFLD. Moreover, hepatic SFRP5 seems to have a protective role in the first steps of NAFLD, but in an advanced stage of the disease, SFRP5 is deregulated while JNK and WNT5A are activated. L'objectiu d'aquest estudi és analitzar el paper de SFRP5 en dones amb obesitat mòrbida i NAFLD. Vam trobar que els nivells de SFRP5 irculant augmenten després d'una restricció calòrica en subjectes amb MO independentment de la NAFLD. A més, l'SFRP5 hepàtic sembla tenir un paper protector en els primers passos de la NAFLD, però en una fase avançada de la malaltia, SFRP5 es desregula mentre s'activen JNK i WNT5A.
    Subject: Bioquímica i biotecnologia
    Language: en
    Subject areas: Bioquímica y biotecnología Biochemistry and biotechnology Bioquímica i biotecnologia
    Department: Bioquímica i Biotecnologia
    Student: Portillo Carrasquer, Marta
    Academic year: 2020-2021
    Title in different languages: Desregulación de Secreted Frizzled-Related Protein 5 en la enfermedad del hígado graso no alcohólico asociada a obesidad Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity Desregulació de Secreted Frizzled-Related Protein 5 en la malaltia de fetge gras no alcohòlic associada a obesitat
    Work's public defense date: 2021-06-29
    Access rights: info:eu-repo/semantics/openAccess
    Keywords: SFRP5, NAFLD, inflamación SFRP5, NAFLD, inflammation SFRP5, NAFLD, inflamació
    Confidenciality: No
    Title in original language: Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity
    Project director: Beltrán Debón, Raúl
    Education area(s): Bioquímica i Biologia Molecular
    Entity: Universitat Rovira i Virgili (URV)
  • Keywords:

    Bioquímica y biotecnología
    Biochemistry and biotechnology
    Bioquímica i biotecnologia
    Bioquímica i biotecnologia
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