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Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity

  • Identification data

    Identifier:  TFG:4464
    Authors:  Portillo Carrasquer, Marta
  • Others:

    Creation date in repository: 2022-03-01
    Abstract: The aim of this study is to analyse the role of SFRP5 in women with morbid obesity and NAFLD. We found that irculating SFRP5 levels increase after a caloric restriction in subjects with MO regardless of NAFLD. Moreover, hepatic SFRP5 seems to have a protective role in the first steps of NAFLD, but in an advanced stage of the disease, SFRP5 is deregulated while JNK and WNT5A are activated.; L'objectiu d'aquest estudi és analitzar el paper de SFRP5 en dones amb obesitat mòrbida i NAFLD. Vam trobar que els nivells de SFRP5 irculant augmenten després d'una restricció calòrica en subjectes amb MO independentment de la NAFLD. A més, l'SFRP5 hepàtic sembla tenir un paper protector en els primers passos de la NAFLD, però en una fase avançada de la malaltia, SFRP5 es desregula mentre s'activen JNK i WNT5A.
    Subject: Bioquímica i biotecnologia
    Language: en
    Subject areas: Bioquímica y biotecnología; Biochemistry and biotechnology; Bioquímica i biotecnologia
    Department: Bioquímica i Biotecnologia
    Student: Portillo Carrasquer, Marta
    Academic year: 2020-2021
    Title in different languages: Desregulación de Secreted Frizzled-Related Protein 5 en la enfermedad del hígado graso no alcohólico asociada a obesidad; Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity; Desregulació de Secreted Frizzled-Related Protein 5 en la malaltia de fetge gras no alcohòlic associada a obesitat
    Work's public defense date: 2021-06-29
    Access rights: info:eu-repo/semantics/openAccess
    Keywords: SFRP5, NAFLD, inflamación; SFRP5, NAFLD, inflammation; SFRP5, NAFLD, inflamació
    Confidenciality: No
    Title in original language: Deregulation of Secreted Frizzled-Related Protein 5 in Nonalcoholic Fatty Liver Disease Associated with Obesity
    Project director: Beltrán Debón, Raúl
    Education area(s): Bioquímica i Biologia Molecular
    Entity: Universitat Rovira i Virgili (URV)
  • Keywords:

    Bioquímica y biotecnología
    Biochemistry and biotechnology
    Bioquímica i biotecnologia
    Bioquímica i biotecnologia
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