Proteomic study of HIV-positive immunological non-responder patients

Identifier:  TFG:5704

Handle: https://hdl.handle.net/20.500.11797/TFG5704

Authors:  Flores Piñas, Marina

Abstract:
A proteomic study was designed to identify protein patterns associated with poor immune response to antiretroviral treatment (ART) administered to HIV-positive individuals. The study of T-cells proteomic profile from seropositive patients before the start of ART revealed significant differences in both cell subtypes between control subjects, subjects initiating ART with low immune status but good immune recovery on ART and those patients with poor immune response on ART. The significant proteins identified should be further studied as possible biomarkers for the early identification of immunological non-responder patients or as therapeutic targets for the improvement of immune recovery status to treatment.