Assessing inter-organ crosstalk in the development of obesity-associated non-alcoholic fatty liver disease

Identifier:  TFG:5724

Handle: https://hdl.handle.net/20.500.11797/TFG5724

Authors:  Vañó Segarra, Irene

Abstract:
Non-alcoholic fatty liver disease (NAFLD) is closely related to obesity, and both diseases are considered a global pandemic. If not treated, NAFLD turns more severe reaching non-alcoholic steatohepatitis (NASH). During the progression of this disease, organs exchange information using organokines, trying to modulate their physiologic status. We sought to determine the concentration of six organokines in plasma and assess their role in the obesity-associated NAFLD progression. We performed a sandwich Enzyme-Linked Immuno Sorbent Assay (ELISA) and found out significant differences between healthy volunteers and NAFL patients. However, only Adiponectin and FGF21 were found to be associated to NAFLD progression.