The effects of the succinate-SUCNR1 axis in foam cells in the context of atherosclerosis

Identifier:  TFG:6015

Handle: https://hdl.handle.net/20.500.11797/TFG6015

Authors:  Alonso Bastida, Nerea

Abstract:
Atherosclerosis (AS) is an inflammatory disease characterized by lipid deposition. Succinate is a metabolite that acts as a signalling molecule through its receptor SUCNR1, and is increased in inflammatory diseases. Succinate-SUCNR1 axis is important for the regulation of the inflammatory response, however, whether succinate-SUCNR1 signalling plays a key role in AS, is still unknown. Since succinate is elevated in cardiometabolic diseases, we hypothesize that succinate-SUCNR1 axis is implied in foam cell formation. We aim to evaluate the succinate-SUCNR1 axis as regulator of foam cell formation, and to assess the utility of succinate as a biomarker in the context of AS.