Alzheimer's disease on it's sporadic form and late onset associated with metabolic disorders: a review of the latest hypotheses.

Identifier:  TFG:875

Handle: https://hdl.handle.net/20.500.11797/TFG875

Authors:  García Segovia, Natalia

Abstract:
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease characterized by memory impairment and altered cognitive function. Several hypotheses have explained its appearance until now. In this paper I revised these hypotheses and, in addition, I present new investigations that show new perspectives about the etiopathogenesis of AD proving that, in the late-onset and sporadic form of the disease, can be considered as a metabolic disease. Then, AD would be mediated by brain dysfunction to insulin response, utilization of glucose and energetic metabolism affected by inflammation process, oxidative stress and worsening insulin resistance. All these dysfunctions are involved in metabolic diseases like obesity, metabolic syndrome and type 2 diabetes (T2D) linked with food patterns. Due to its relation with insulin resistance and T2D, AD has been denominated type 3 diabetes (T3D). Moreover, this review emphasizes the role of diet, in prevention of AD, specifically the Mediterranean Diet. The evidence demonstrates that Mediterranean Diet has different components that play a neuroprotective role to prevent the AD and impacts on the possible mechanisms involved.