Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors

Entity: Universitat Rovira i Virgili (URV)

Confidenciality: No

Education area(s): Síntesi, Catàlisi i Disseny Molecular

APS: NO

Title in different languages: Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors

Abstract: The stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential Des 1 inhibitors is presented. By harnessing the singular reactivity of cyclopropenones one of the potential Des1 inhibitors, bearing a 1,2-dichalcogen heterocycle, has been synthesized in an effective and time-saving manner via late-stage functionalization. Docking studies support their potential as Des1 inhibitors. Both synthetized compounds will be evaluated as Des1 inhibitors

Subject: química

Academic year: 2021-2022

Language: en

Work's public defense date: 2022-07-21

Subject areas: Chemistry

Student: Figueras Boldó, Adrià

Department: Química Analítica i Química Orgànica

Creation date in repository: 2023-05-22

Keywords: stereoselective synthesis, cyclopropenone, dihydroceramide desaturase 1 (Des1)

Title in original language: Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors

Access Rights: info:eu-repo/semantics/openAccess

Project director: Matheu Malpartida, Maria Isabel