Keywords: síntesi estereoselectiva, ciclopropenona, dihidroceramida desaturasa 1 (Des1) stereoselective synthesis, cyclopropenone, dihydroceramide desaturase 1 (Des1) síntesis estereoselectiva, ciclopropenona, dihidroceramida desaturasa 1 (Des1)
Title in different languages: Síntesi estereoselectiva de derivats de la ceramida basats en la ciclopropenona com a possibles inhibidors de la dihidroceramida desaturasa 1 Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors Síntesis estereoselectiva de derivados de la ceramida basados en la ciclopropenona como posibles inhibidores de la dihidroceramida desaturasa 1
Subject areas: Química Chemistry Química
Confidenciality: No
Academic year: 2021-2022
Student: Figueras Boldó, Adrià
APS: NO
Department: Química Analítica i Química Orgànica
Access Rights: info:eu-repo/semantics/openAccess
Work's public defense date: 2022-07-21
Project director: Matheu Malpartida, Maria Isabel
Abstract: Es presenta la síntesi estereoselectiva de derivats de ceramida basats en ciclopropenona com a inhibidors potencials de Des 1. Mitjançant l'aprofitament de la reactivitat singular de les ciclopropenones, s'ha sintetitzat un dels possibles inhibidors de Des1, que porta un heterocicle d'1,2-dicalcogen, de manera eficaç i estalviant temps mitjançant la funcionalització en fase tardana. Els estudis d'acoblament donen suport al seu potencial com a inhibidors de Des1. Tots dos compostos sintetitzats seran avaluats com a inhibidors de Des1 The stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential Des 1 inhibitors is presented. By harnessing the singular reactivity of cyclopropenones one of the potential Des1 inhibitors, bearing a 1,2-dichalcogen heterocycle, has been synthesized in an effective and time-saving manner via late-stage functionalization. Docking studies support their potential as Des1 inhibitors. Both synthetized compounds will be evaluated as Des1 inhibitors
Subject: química
Entity: Universitat Rovira i Virgili (URV)
Language: en
Education area(s): Síntesi, Catàlisi i Disseny Molecular
Title in original language: Stereoselective synthesis of cyclopropenone-based ceramide derivatives as potential dihydroceramide desaturase 1 inhibitors
Creation date in repository: 2023-05-22
Repositori URV